Int. J. Environ. Res. Public Health 2010, 7(5), 1872-1888; doi:10.3390/ijerph7051872
Molecular Basis and Current Treatment for Alcoholic Liver Disease
1
Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Jalisco 44281, Mexico
2
OPD Hospital Civil de Guadalajara, Jalisco 44340, Mexico
*
Author to whom correspondence should be addressed.
Received: 18 February 2010 / Accepted: 5 March 2010 / Published: 27 April 2010
(This article belongs to the Special Issue Alcohol and Public Health)
Abstract
Alcohol use disorders and alcohol dependency affect millions of individuals worldwide. The impact of these facts lies in the elevated social and economic costs. Alcoholic liver disease is caused by acute and chronic exposure to ethanol which promotes oxidative stress and inflammatory response. Chronic consumption of ethanol implies liver steatosis, which is the first morphological change in the liver, followed by liver fibrosis and cirrhosis. This review comprises a broad approach of alcohol use disorders, and a more specific assessment of the pathophysiologic molecular basis, and genetics, as well as clinical presentation and current modalities of treatment for alcoholic liver disease. View Full-TextKeywords:
alcohol; alcoholism; fibrosis; cirrhosis; alcoholic liver disease
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Miranda-Mendez, A.; Lugo-Baruqui, A.; Armendariz-Borunda, J. Molecular Basis and Current Treatment for Alcoholic Liver Disease. Int. J. Environ. Res. Public Health 2010, 7, 1872-1888.
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