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Molecular Basis and Current Treatment for Alcoholic Liver Disease
Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Jalisco 44281, Mexico
OPD Hospital Civil de Guadalajara, Jalisco 44340, Mexico
* Author to whom correspondence should be addressed.
Received: 18 February 2010 / Accepted: 5 March 2010 / Published: 27 April 2010
Abstract: Alcohol use disorders and alcohol dependency affect millions of individuals worldwide. The impact of these facts lies in the elevated social and economic costs. Alcoholic liver disease is caused by acute and chronic exposure to ethanol which promotes oxidative stress and inflammatory response. Chronic consumption of ethanol implies liver steatosis, which is the first morphological change in the liver, followed by liver fibrosis and cirrhosis. This review comprises a broad approach of alcohol use disorders, and a more specific assessment of the pathophysiologic molecular basis, and genetics, as well as clinical presentation and current modalities of treatment for alcoholic liver disease.
Keywords: alcohol; alcoholism; fibrosis; cirrhosis; alcoholic liver disease
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MDPI and ACS Style
Miranda-Mendez, A.; Lugo-Baruqui, A.; Armendariz-Borunda, J. Molecular Basis and Current Treatment for Alcoholic Liver Disease. Int. J. Environ. Res. Public Health 2010, 7, 1872-1888.
Miranda-Mendez A, Lugo-Baruqui A, Armendariz-Borunda J. Molecular Basis and Current Treatment for Alcoholic Liver Disease. International Journal of Environmental Research and Public Health. 2010; 7(5):1872-1888.
Miranda-Mendez, Alejandra; Lugo-Baruqui, Alejandro; Armendariz-Borunda, Juan. 2010. "Molecular Basis and Current Treatment for Alcoholic Liver Disease." Int. J. Environ. Res. Public Health 7, no. 5: 1872-1888.