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Int. J. Environ. Res. Public Health 2009, 6(11), 2752-2761; doi:10.3390/ijerph6112752
Review

Is There a Link between Wheezing in Early Childhood and Adverse Birth Outcomes? A Systematic Review

1,* , 2
,
3
 and
4
1 University Hospital of Heraklion, Crete, 71414 Greece 2 Independent Researcher, Crete, Heraklion, 71500 Greece 3 Department of Midwifery, Technological Educational Institution, Athens, 12210 Greece 4 Faculty of Nursing, University of Athens, 11527 Greece
* Author to whom correspondence should be addressed.
Received: 24 August 2009 / Accepted: 29 October 2009 / Published: 3 November 2009
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Abstract

We aimed to provide a summary of the existing published knowledge on the association between adverse birth outcomes and the development of wheezing during the first two years of life. We carried out a systematic review of epidemiological studies within the MEDLINE database. Epidemiological studies on human subjects, published in English, were included in the review. A comprehensive literature search yielded 72 studies for further consideration. Following the application of the eligibility criteria we identified nine studies. A positive association and an excess risk of wheezing during the first two years of life were revealed for adverse birth outcomes.
Keywords: adverse birth outcomes; low birth weight; preterm; wheezing; respiratory disorder; asthma adverse birth outcomes; low birth weight; preterm; wheezing; respiratory disorder; asthma
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Patelarou, E.; Chochlidaki, M.; Vivilaki, V.; Brokalaki, H. Is There a Link between Wheezing in Early Childhood and Adverse Birth Outcomes? A Systematic Review. Int. J. Environ. Res. Public Health 2009, 6, 2752-2761.

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