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Int. J. Environ. Res. Public Health 2009, 6(11), 2752-2761; doi:10.3390/ijerph6112752
Review

Is There a Link between Wheezing in Early Childhood and Adverse Birth Outcomes? A Systematic Review

1,* , 2
, 3
 and 4
Received: 24 August 2009; Accepted: 29 October 2009 / Published: 3 November 2009
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Abstract: We aimed to provide a summary of the existing published knowledge on the association between adverse birth outcomes and the development of wheezing during the first two years of life. We carried out a systematic review of epidemiological studies within the MEDLINE database. Epidemiological studies on human subjects, published in English, were included in the review. A comprehensive literature search yielded 72 studies for further consideration. Following the application of the eligibility criteria we identified nine studies. A positive association and an excess risk of wheezing during the first two years of life were revealed for adverse birth outcomes.
Keywords: adverse birth outcomes; low birth weight; preterm; wheezing; respiratory disorder; asthma adverse birth outcomes; low birth weight; preterm; wheezing; respiratory disorder; asthma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Patelarou, E.; Chochlidaki, M.; Vivilaki, V.; Brokalaki, H. Is There a Link between Wheezing in Early Childhood and Adverse Birth Outcomes? A Systematic Review. Int. J. Environ. Res. Public Health 2009, 6, 2752-2761.

AMA Style

Patelarou E, Chochlidaki M, Vivilaki V, Brokalaki H. Is There a Link between Wheezing in Early Childhood and Adverse Birth Outcomes? A Systematic Review. International Journal of Environmental Research and Public Health. 2009; 6(11):2752-2761.

Chicago/Turabian Style

Patelarou, Evridiki; Chochlidaki, Maria; Vivilaki, Victoria; Brokalaki, Hero. 2009. "Is There a Link between Wheezing in Early Childhood and Adverse Birth Outcomes? A Systematic Review." Int. J. Environ. Res. Public Health 6, no. 11: 2752-2761.



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