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Int. J. Environ. Res. Public Health 2008, 5(5), 394-398; doi:10.3390/ijerph5050394
Article

A Method to Compute Multiplicity Corrected Confidence Intervals for Odds Ratios and Other Relative Effect Estimates

1,*  and 2
1 Division of Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, S.9.548 (MLC 7000), Cincinnati, Ohio 45229-3039, USA 2 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Cancer Epidemiology Research Cooperative, POB 19024, 1100 Fairview Ave, North, MS M4-C308, Seattle, Washington 98109-1024, USA
* Author to whom correspondence should be addressed.
Received: 21 September 2008 / Accepted: 24 November 2008 / Published: 31 December 2008
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Abstract

Epidemiological studies commonly test multiple null hypotheses. In some situations it may be appropriate to account for multiplicity using statistical methodology rather than simply interpreting results with greater caution as the number of comparisons increases. Given the one-to-one relationship that exists between confidence intervals and hypothesis tests, we derive a method based upon the Hochberg step-up procedure to obtain multiplicity corrected confidence intervals (CI) for odds ratios (OR) and by analogy for other relative effect estimates. In contrast to previously published methods that explicitly assume knowledge of P values, this method only requires that relative effect estimates and corresponding CI be known for each comparison to obtain multiplicity corrected CI.
Keywords: Multiplicity correction; Hochberg step-up procedure Multiplicity correction; Hochberg step-up procedure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Efird, J.T.; Nielsen, S.S. A Method to Compute Multiplicity Corrected Confidence Intervals for Odds Ratios and Other Relative Effect Estimates. Int. J. Environ. Res. Public Health 2008, 5, 394-398.

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Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert