Int. J. Environ. Res. Public Health 2005, 2(3), 430-441; doi:10.3390/ijerph2005030007
Review

Environmental Toxicology and Health Effects Associated with Methyl Parathion Exposure – A Scientific Review

 and * email
Received: 3 July 2005; Accepted: 4 December 2005 / Published: 30 December 2005
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Methyl parathion - MP (C8H10NO5PS) is a restricted-use pesticide that has been widely used as an agricultural insecticide. It belongs to the class of organophosphate chemicals characterized by their ability to inhibit acetylcholinesterase activity. The main route of human exposure is inhalation, but dermal contact and inadvertent ingestion can also be substantial. Populations that are susceptible to MP exposure primarily are applicators, manufacturers and individuals living near application and/or disposal sites. Exposure has also been reported as a result of illegal indoor application. MP related health effects include headaches, nausea, night-waking, diarrhea, difficulty breathing, excessive sweating and salivation, incoordination, and mental confusion. Other symptoms including behavior problems, motor skill problems and impairment of memory recall have also been reported. The primary targets of toxicity are the hematopoietic system (serum cholinesterase inhibition), the cardiovascular system (cardiovascular lesions, abnormalities in heart rate and increase in heart-to-body ratio), the reproductive system (placental morphology, fibrosis and hemorrhage, and inhibition of DNA synthesis in seminiferous tubules), and the nervous system (headache, muscle weakness, insomnia, dizziness, and impaired memory). MP is believed to not have any carcinogenic effects. In an attempt to update its toxicologic profile, we hereby provide a critical review of MP-related environmental and toxicologic effects, with a special emphasis on their potential implications for public health.
Keywords: Methyl parathion; toxicokinetics; systemic toxicity; genotoxicity; neurotoxicity; carcinogenicity; health effects
PDF Full-text Download PDF Full-Text [455 KB, uploaded 19 June 2014 00:07 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Edwards, F.L.; Tchounwou, P.B. Environmental Toxicology and Health Effects Associated with Methyl Parathion Exposure – A Scientific Review. Int. J. Environ. Res. Public Health 2005, 2, 430-441.

AMA Style

Edwards FL, Tchounwou PB. Environmental Toxicology and Health Effects Associated with Methyl Parathion Exposure – A Scientific Review. International Journal of Environmental Research and Public Health. 2005; 2(3):430-441.

Chicago/Turabian Style

Edwards, Falicia L.; Tchounwou, Paul B. 2005. "Environmental Toxicology and Health Effects Associated with Methyl Parathion Exposure – A Scientific Review." Int. J. Environ. Res. Public Health 2, no. 3: 430-441.

Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert