Next Article in Journal
Acknowledgement to Reviewers of IJERPH in 2017
Next Article in Special Issue
Examining the Impact of Maternal Individual Features on Children’s Behavioral Problems in Adoptive Families: The Role of Maternal Temperament and Neurobiological Markers
Previous Article in Journal
Inhibiting the Physiological Stress Effects of a Sustained Attention Task on Shoulder Muscle Activity
Previous Article in Special Issue
Preventive Effect of Residential Green Space on Infantile Atopic Dermatitis Associated with Prenatal Air Pollution Exposure
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessFeature PaperArticle
Int. J. Environ. Res. Public Health 2018, 15(1), 120; https://doi.org/10.3390/ijerph15010120

Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan
*
Author to whom correspondence should be addressed.
Received: 12 October 2017 / Revised: 20 December 2017 / Accepted: 9 January 2018 / Published: 11 January 2018
(This article belongs to the Special Issue Maternal and Child Health 2018)
View Full-Text   |   Download PDF [500 KB, uploaded 11 January 2018]   |  

Abstract

Studies have suggested associations between maternal obesity and mental health problems of their children. However, the underlying mechanism is largely unknown. A possible mechanism can be via inflammatory states and the other possible mechanism is metabolic hormone-induced programming. Cross-talk between adipokines, including inflammatory cytokines and metabolic hormones secreted from adipose tissue and the central nervous system needs to be further investigated to elucidate the mechanism. Thus, the aim of this study was to investigate the association between fetal adipokine levels and child behavioral problems at preschool age. Cord blood adiponectin, leptin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) levels were measured and child behavioral problems were assessed using the Strengths and Difficulties Questionnaire at preschool age. Logistic regression models adjusted by related maternal factors were performed to examine the association between cord blood adipokines and child behavioral problems. Three hundred and sixty-one children were included in the final analysis. A significant association between decreased hyperactivity/inattention and increased leptin was found (OR = 0.22, 95% CI: 0.06–0.89). Cord blood adiponectin, TNF-α and IL-6 levels were not associated with child behavioral problems. Our findings suggested that cord blood adipokines, particularly, leptin level, may be a predictor of hyperactivity/inattention problems at preschool age. View Full-Text
Keywords: Strengths and Difficulties Questionnaire (SDQ); adipokines; child behavioral problems; birth cohort study Strengths and Difficulties Questionnaire (SDQ); adipokines; child behavioral problems; birth cohort study
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Minatoya, M.; Itoh, S.; Araki, A.; Tamura, N.; Yamazaki, K.; Miyashita, C.; Kishi, R. Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health. Int. J. Environ. Res. Public Health 2018, 15, 120.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top