Int. J. Environ. Res. Public Health 2017, 14(8), 855; doi:10.3390/ijerph14080855
Unusual Onset of Celiac Disease and Addison’s Disease in a 12-Year-Old Boy
Francesco Miconi 1, Emanuela Savarese 1, Giovanni Miconi 1, Gabriele Cabiati 1, Valentina Rapaccini 1, Nicola Principi 2 and Susanna Esposito 3,*
1
Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy
2
Pediatric Highly Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy
3
Paediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy
*
Author to whom correspondence should be addressed.
Received: 4 July 2017 / Revised: 26 July 2017 / Accepted: 28 July 2017 / Published: 29 July 2017
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
Abstract
Background: Celiac disease (CD) is an autoimmune disorder deriving from an aberrant adaptive immune response against gluten-containing grains in genetically predisposed subjects. In a number of patients, CD is associated with one or more other autoimmune diseases. Primary Addison’s disease (AD) and CD may co-exist, although this association is relatively uncommon in children. In addition, it is not precisely defined whether a gluten-free diet influences the course of AD. Case presentation: A case of CD in a 12-year-old boy presenting as acute adrenal insufficiency is described here. A gluten-free diet had a significant therapeutic role in this case, wherein most of the clinical signs and symptoms of AD disappeared in a few days. In addition, the dosage of cortisol acetate, initially administered to treat the AD, was able to be rapidly reduced. Conclusion: This case highlights that CD can be associated with AD in children, and a gluten-free diet seems to positively influence the course of AD. View Full-Text
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Miconi, F.; Savarese, E.; Miconi, G.; Cabiati, G.; Rapaccini, V.; Principi, N.; Esposito, S. Unusual Onset of Celiac Disease and Addison’s Disease in a 12-Year-Old Boy. Int. J. Environ. Res. Public Health 2017, 14, 855.
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