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Int. J. Environ. Res. Public Health 2017, 14(6), 572; doi:10.3390/ijerph14060572

FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes

1
Department of Public Health and Environmental Medicine and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
2
Department of Nutrition and Dietetics, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan
3
Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
4
Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan
5
School of Public Health, University of Queensland, Brisbane, Queensland 4006, Australia
6
Department of Nutrition and Health Sciences, College of Health Sciences, Chang-Jung Christian University, Tainan 71101, Taiwan
7
Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan
8
Department of Health Services Administration, China Medical University, Taichung 40402, Taiwan
9
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University and University Hospital, Kaohsiung 80708, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 16 April 2017 / Revised: 20 May 2017 / Accepted: 20 May 2017 / Published: 28 May 2017
(This article belongs to the Section Global Health)
View Full-Text   |   Download PDF [429 KB, uploaded 28 May 2017]   |  

Abstract

Polyunsaturated fatty acids (PUFA) correlate with risk of dyslipidemia and cardiovascular diseases. Fatty acid desaturase (FADS) single nucleotide polymorphisms (SNPs) modulate circulating PUFA concentrations. This study examined influence of FADS1 and FADS2 genetic variants on desaturase activities and blood lipid concentrations in type 2 diabetes patients, and further assessed their interrelationships. Selected SNPs (FADS1: rs174547, rs174548, rs174550; FADS2: rs174575, rs174576, rs174583, rs498793 and rs2727270) were genotyped in 820 type 2 diabetes patients and compared with those reported in the HapMap. Patient subgroups (n = 176) without taking lipid-lowering medicine were studied to assess influence of tag SNPs including rs174547, rs174575, rs498793 and rs2727270 on delta-5 desaturase (D5D: 20:4 (n-6)/20:3 (n-6)) and delta-6 desaturase (D6D:18:3 (n-6)/18:2 (n-6)) activities, and blood lipids. FADS1 rs174547 TT/TC/CC and FADS2 rs2727270 CC/CT/TT were significantly (p for trend < 0.05) associated with reduced HDL-C, D5D and D6D activities. Upon adjustment for confounders, D5D (p = 0.006) correlated significantly and D6D marginally (p = 0.07) correlated with increased HDL-C levels, whereas rs174547 and rs2727270 polymorphisms were not associated. D6D andD5D activities may play a role in modulating HDL-C levels in type 2 diabetes. Future studies with larger sample sizes are needed to investigate how FADS genetic variations interact with desaturase activities or PUFAs in the metabolism of lipoproteins in diabetic patients. View Full-Text
Keywords: diabetes; FADS1; FADS2; HDL; genetic polymorphisms; polyunsaturated fatty acids diabetes; FADS1; FADS2; HDL; genetic polymorphisms; polyunsaturated fatty acids
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MDPI and ACS Style

Huang, M.-C.; Chang, W.-T.; Chang, H.-Y.; Chung, H.-F.; Chen, F.-P.; Huang, Y.-F.; Hsu, C.-C.; Hwang, S.-J. FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes. Int. J. Environ. Res. Public Health 2017, 14, 572.

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