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Int. J. Environ. Res. Public Health 2017, 14(5), 500; doi:10.3390/ijerph14050500

The Presence of Anti-Angiotensin II Type-1 Receptor Antibodies Adversely Affect Kidney Graft Outcomes

1,2,3,†
,
3,†
,
3,†
,
4,* , 1,* and 3,5,*
1
The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, 277 Yanta West Road, Xi’an 710061, China
2
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
3
School of Public Health, Xi’an Jiaotong University Health Science Center, 76 Yanta West Road, Xi’an 710061, China
4
Xi’an Honghui Hospital, 555 Friendship Road, Xi’an 710054, China
5
Key Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education of China, Xi’an 710061, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 16 February 2017 / Revised: 24 March 2017 / Accepted: 19 April 2017 / Published: 9 May 2017
(This article belongs to the Section Global Health)
View Full-Text   |   Download PDF [4721 KB, uploaded 9 May 2017]   |  

Abstract

The aim of this study was to determine whether anti-angiotensin type 1 receptor antibodies (AT1R-Abs) are related to acute rejection (AR) and kidney graft failure in renal transplantation. We searched electronic databases including MEDLINE, EMBASE, and the ISI Web of Science databases for all studies on the association between anti-angiotensin type 1 receptor antibodies and kidney allograft outcomes updated to November 2016. Reference lists from included articles were also reviewed. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were extracted or calculated using a random-effects model. The potential sources of heterogeneity and publication bias were estimated. Nine studies enrolling 1771 subjects were retrieved in the meta-analysis. AT1R-Abs showed significant associations with increased risk of AR (RR = 1.66; 95% CI, 1.23–2.09). In addition, a significant relationship was found between AT1R-Abs and kidney graft failure compared with AR (RR = 3.02; 95% CI, 1.77–4.26). The results were essentially consistent among subgroups stratified by participant characteristics. These results demonstrated that the AT1R-Abs were associated with an elevated risk of kidney allograft outcomes, especially with kidney graft failure. Large-scale studies are still required to further verify these findings. View Full-Text
Keywords: angiotensin II type 1 receptor antibody; angiotensin II receptor; kidney transplantation; acute rejection; meta-analysis angiotensin II type 1 receptor antibody; angiotensin II receptor; kidney transplantation; acute rejection; meta-analysis
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MDPI and ACS Style

Zhang, J.; Wang, M.; Liang, J.; Zhang, M.; Liu, X.-H.; Ma, L. The Presence of Anti-Angiotensin II Type-1 Receptor Antibodies Adversely Affect Kidney Graft Outcomes. Int. J. Environ. Res. Public Health 2017, 14, 500.

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