Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis
AbstractBackground: Lipoma preferred partner (LPP) and T-cell activation Rho GTPase activating protein (TAGAP) polymorphisms might influence the susceptibility to celiac disease. Therefore, we performed a meta-analysis by identifying relevant studies to estimate the risks of these polymorphisms on celiac disease. Methods: The PubMed, Web of Science and Embase databases were searched (up to October 2016) for LPP rs1464510 and TAGAP rs1738074 polymorphisms. Results: This meta-analysis included the same 7 studies for LPP rs1464510 and TAGAP rs1738074. The minor risk A allele at both rs1464510 and rs1738074 carried risks (odds ratios) of 1.26 (95% CI: 1.22–1.30) and 1.17 (95% CI: 1.14–1.21), respectively, which contributed to increased risks in all celiac disease patients by 10.72% and 6.59%, respectively. The estimated lambdas were 0.512 and 0.496, respectively, suggesting that a co-dominant model would be suitable for both gene effects. Conclusions: This meta-analysis provides robust estimates that polymorphisms in LPP and TAGAP genes are potential risk factors for celiac disease in European and American. Prospective studies and more genome-wide association studies (GWAS) are needed to confirm these findings, and some corresponding molecular biology experiments should be carried out to clarify the pathogenic mechanisms of celiac disease. View Full-Text
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Huang, S.-Q.; Zhang, N.; Zhou, Z.-X.; Huang, C.-C.; Zeng, C.-L.; Xiao, D.; Guo, C.-C.; Han, Y.-J.; Ye, X.-H.; Ye, X.-G.; Ou, M.-L.; Zhang, B.-H.; Liu, Y.; Zeng, E.Y.; Yang, G.; Jing, C.-X. Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis. Int. J. Environ. Res. Public Health 2017, 14, 171.
Huang S-Q, Zhang N, Zhou Z-X, Huang C-C, Zeng C-L, Xiao D, Guo C-C, Han Y-J, Ye X-H, Ye X-G, Ou M-L, Zhang B-H, Liu Y, Zeng EY, Yang G, Jing C-X. Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis. International Journal of Environmental Research and Public Health. 2017; 14(2):171.Chicago/Turabian Style
Huang, Shi-Qi; Zhang, Na; Zhou, Zi-Xing; Huang, Chui-Can; Zeng, Cheng-Li; Xiao, Di; Guo, Cong-Cong; Han, Ya-Jing; Ye, Xiao-Hong; Ye, Xing-Guang; Ou, Mei-Ling; Zhang, Bao-Huan; Liu, Yang; Zeng, Eddy Y.; Yang, Guang; Jing, Chun-Xia. 2017. "Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis." Int. J. Environ. Res. Public Health 14, no. 2: 171.
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