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Int. J. Environ. Res. Public Health 2017, 14(2), 171; doi:10.3390/ijerph14020171

Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis

1
Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China
2
Department of Preventive Medicine, Zunyi Medical College, Zhuhai Campus, Zhuhai 519041, Guangdong, China
3
School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, Guangdong, China
4
Department of Parasitology, School of Basic Medical Sciences, Jinan University, Guangzhou 510632, Guangdong, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 1 December 2016 / Accepted: 31 January 2017 / Published: 10 February 2017
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Abstract

Background: Lipoma preferred partner (LPP) and T-cell activation Rho GTPase activating protein (TAGAP) polymorphisms might influence the susceptibility to celiac disease. Therefore, we performed a meta-analysis by identifying relevant studies to estimate the risks of these polymorphisms on celiac disease. Methods: The PubMed, Web of Science and Embase databases were searched (up to October 2016) for LPP rs1464510 and TAGAP rs1738074 polymorphisms. Results: This meta-analysis included the same 7 studies for LPP rs1464510 and TAGAP rs1738074. The minor risk A allele at both rs1464510 and rs1738074 carried risks (odds ratios) of 1.26 (95% CI: 1.22–1.30) and 1.17 (95% CI: 1.14–1.21), respectively, which contributed to increased risks in all celiac disease patients by 10.72% and 6.59%, respectively. The estimated lambdas were 0.512 and 0.496, respectively, suggesting that a co-dominant model would be suitable for both gene effects. Conclusions: This meta-analysis provides robust estimates that polymorphisms in LPP and TAGAP genes are potential risk factors for celiac disease in European and American. Prospective studies and more genome-wide association studies (GWAS) are needed to confirm these findings, and some corresponding molecular biology experiments should be carried out to clarify the pathogenic mechanisms of celiac disease. View Full-Text
Keywords: LPP; TAGAP; polymorphism; celiac disease; meta-analysis LPP; TAGAP; polymorphism; celiac disease; meta-analysis
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Huang, S.-Q.; Zhang, N.; Zhou, Z.-X.; Huang, C.-C.; Zeng, C.-L.; Xiao, D.; Guo, C.-C.; Han, Y.-J.; Ye, X.-H.; Ye, X.-G.; Ou, M.-L.; Zhang, B.-H.; Liu, Y.; Zeng, E.Y.; Yang, G.; Jing, C.-X. Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis. Int. J. Environ. Res. Public Health 2017, 14, 171.

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