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Int. J. Environ. Res. Public Health 2017, 14(1), 93; doi:10.3390/ijerph14010093

Genetic Aspects of Susceptibility to Mercury Toxicity: An Overview

Institute of Atmospheric Pollution Research, National Research Council of Italy, Division of Rende, Rende 87036, Italy
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Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 3 November 2016 / Revised: 16 December 2016 / Accepted: 12 January 2017 / Published: 18 January 2017
(This article belongs to the Special Issue Mercury and Health: Current Perspectives and Future Directions)
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Abstract

Human exposure to mercury is still a major public health concern. In this context, children have a higher susceptibility to adverse neurological mercury effects, compared to adults with similar exposures. Moreover, there exists a marked variability of personal response to detrimental mercury action, in particular among population groups with significant mercury exposure. New scientific evidence on genetic backgrounds has raised the issue of whether candidate susceptibility genes can make certain individuals more or less vulnerable to mercury toxicity. In this review, the aim is to evaluate a new genetic dimension and its involvement in mercury risk assessment, focusing on the important role played by relevant polymorphisms, located in attractive gene targets for mercury toxicity. Existing original articles on epidemiologic research which report a direct link between the genetic basis of personal vulnerability and different mercury repercussions on human health will be reviewed. Based on this evidence, a careful evaluation of the significant markers of susceptibility will be suggested, in order to obtain a powerful positive “feedback” to improve the quality of life. Large consortia of studies with clear phenotypic assessments will help clarify the “window of susceptibility” in the human health risks due to mercury exposure. View Full-Text
Keywords: mercury; toxicokinetics; human health; risk assessment; children exposure; environmental genetics; DNA variants; biomarkers of susceptibility mercury; toxicokinetics; human health; risk assessment; children exposure; environmental genetics; DNA variants; biomarkers of susceptibility
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Andreoli, V.; Sprovieri, F. Genetic Aspects of Susceptibility to Mercury Toxicity: An Overview. Int. J. Environ. Res. Public Health 2017, 14, 93.

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