Next Article in Journal
Socio-Environmental and Hematological Profile of Landfill Residents (São Jorge Landfill–Sao Paulo, Brazil)
Previous Article in Journal
Acknowledgement to Reviewers of IJERPH in 2016
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2017, 14(1), 63; doi:10.3390/ijerph14010063

Meta-Prediction of the Effect of Methylenetetrahydrofolate Reductase Polymorphisms and Air Pollution on Alzheimer’s Disease Risk

1
Department of Nursing, Yuanpei University of Medical Technology, No.306, Yuanpei Street, Hsinchu 30015, Taiwan
2
Graduate Institute of Clinical Medical Sciences, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan
3
College of Nursing, Augusta University (Previously Georgia Regents University), 987 St. Sebastian Way, EC 4505, Augusta, GA 30912, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Martin Röösli
Received: 15 November 2016 / Revised: 28 December 2016 / Accepted: 5 January 2017 / Published: 11 January 2017
(This article belongs to the Section Global Health)
View Full-Text   |   Download PDF [990 KB, uploaded 11 January 2017]   |  

Abstract

Background: Alzheimer’s disease (AD) is a significant public health issue. AD has been linked with methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, but the findings have been inconsistent. The purpose of this meta-predictive analysis is to examine the associations between MTHFR polymorphisms and epigenetic factors, including air pollution, with AD risk using big data analytics approaches. Methods and Results: Forty-three studies (44 groups) were identified by searching various databases. MTHFR C677T TT and CT genotypes had significant associations with AD risk in all racial populations (RR = 1.13, p = 0.0047; and RR = 1.12, p < 0.0001 respectively). Meta-predictive analysis showed significant increases of percentages of MTHFR C677T polymorphism with increased air pollution levels in both AD case group and control group (p = 0.0021–0.0457); with higher percentages of TT and CT genotypes in the AD case group than that in the control group with increased air pollution levels. Conclusions: The impact of MTHFR C677T polymorphism on susceptibility to AD was modified by level of air pollution. Future studies are needed to further examine the effects of gene-environment interactions including air pollution on AD risk for world populations. View Full-Text
Keywords: meta-analysis; methylenetetrahydrofolate reductase gene; Alzheimer’s disease meta-analysis; methylenetetrahydrofolate reductase gene; Alzheimer’s disease
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wu, S.-M.; Chen, Z.-F.; Young, L.; Shiao, S.P.K. Meta-Prediction of the Effect of Methylenetetrahydrofolate Reductase Polymorphisms and Air Pollution on Alzheimer’s Disease Risk. Int. J. Environ. Res. Public Health 2017, 14, 63.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top