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Int. J. Environ. Res. Public Health 2017, 14(1), 38; doi:10.3390/ijerph14010038

Determinants of Quality of Life in High-Dose Benzodiazepine Misusers

1
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Piazzale Scuro 10, Verona 37134, Italy
2
Department of Internal Medicine, Addiction Unit, Verona University Hospital, Piazzale Scuro 10, Verona 37134, Italy
3
Alcohol Use Disorders Unit, Department of Internal Medicine, Gastroenterology and Hepatology, Catholic University of Rome, Rome 00168, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 9 October 2016 / Revised: 20 December 2016 / Accepted: 29 December 2016 / Published: 4 January 2017
(This article belongs to the Section Global Health)
View Full-Text   |   Download PDF [605 KB, uploaded 4 January 2017]   |  

Abstract

Benzodiazepines (BZDs) are among the most widely prescribed drugs in developed countries, but they have a high potential for tolerance, dependence and misuse. High-dose BZD misuse represents an emerging addiction phenomenon, but data on quality of life (QoL) in high-dose BZD misusers are scant. This study aimed to explore QoL in high-dose BZD misuse. We recruited 267 high-dose BZD misusers, compared the QoL scores in those who took BZD only to poly-drug misusers, and explored the role of demographic and clinical covariates through multivariable analysis. Our data confirmed worse QoL in high-dose BZD misusers and showed that (a) QoL scores were not negatively influenced by the misuse of alcohol or other drugs, or by coexisting psychiatric disorders; (b) demographic variables turned out to be the most significant predictors of QoL scores; (c) BZD intake significantly and negatively influenced QoL. Physical and psychological dimensions of QoL are significantly lower in high-dose BZD misusers with no significant effect of comorbidities. Our data suggest that the main reason for poor QoL in these patients is high-dose BZD intake per se. QoL should be considered among outcome measures in these patients. View Full-Text
Keywords: 12-Items General Health Questionnaire (GHQ-12); addiction; benzodiazepine (BZD); drug misuse; multivariable analysis; patient-centered outcomes; quality of life (QoL); Short Form-36 (SF-36) 12-Items General Health Questionnaire (GHQ-12); addiction; benzodiazepine (BZD); drug misuse; multivariable analysis; patient-centered outcomes; quality of life (QoL); Short Form-36 (SF-36)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tamburin, S.; Federico, A.; Faccini, M.; Casari, R.; Morbioli, L.; Sartore, V.; Mirijello, A.; Addolorato, G.; Lugoboni, F. Determinants of Quality of Life in High-Dose Benzodiazepine Misusers. Int. J. Environ. Res. Public Health 2017, 14, 38.

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