Next Article in Journal
Antioxidant Pre-Treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis
Previous Article in Journal
Toward a Socio-Territorial Approach to Health: Health Equity in West Africa
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2017, 14(1), 107; doi:10.3390/ijerph14010107

Acute Anterior Uveitis as a Risk Factor of Ankylosing Spondylitis—A National Population-Based Study

1
Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
2
Department of Ophthalmology, Ren-Ai Branch, Taipei City Hospital, Taipei 10629, Taiwan
3
School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
4
Department of Neurosurgery, Ren-Ai Branch, Taipei City Hospital, Taipei 10629, Taiwan
5
Department of Psychology, National Chengchi University, Taipei 11605, Taiwan
6
Ministry of Health and Welfare, Taipei 11558, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 13 November 2016 / Revised: 11 January 2017 / Accepted: 19 January 2017 / Published: 23 January 2017
(This article belongs to the Section Global Health)
View Full-Text   |   Download PDF [700 KB, uploaded 23 January 2017]   |  

Abstract

Introduction: In clinical settings, acute anterior uveitis (AAU) could be the first presentation of ankylosing spondylitis (AS). Based on this hypothesis, we investigate whether AAU is a risk factor in developing AS later by using National Health Insurance Research Database (NHIRD) in Taiwan. Materials and Methods: This cohort comparison study used longitudinal Taiwanese NHIRD to probe the relative risk odds of AAU for AS development, and consisted of all patients diagnosed with AAU (n = 5621) (ICD-9-CM codes 364.00). The relative risks of AS between AAU patients and controls were compared by estimating the crude hazard ratio with logistic regression. Kaplan–Meier analysis was used to calculate the cumulative incidence rates of developing AS, and a log-rank test was used to analyze the differences between the survival curves. Separate Cox proportional hazard regressions were performed to compute the AS-free rate after adjusting for possible confounding factors such as age and sex. Results: The crude hazard ratio was 2.667 for the AAU group, and the adjusted hazard ratio was 2.705 for the AAU group. The observation time of the AS-free group was shorter for AAU patients compared with the control group (1507 versus 1578 days). Moreover, in the AAU patients, the younger age onset of AAU (less than 30 years old here) would lead to an earlier diagnosis of AS later with a median of 1445.5 (742–2241) versus 1544 (819–2289) days of survival for the group of age onset of AAU greater than 30 years old. The difference is statistically significant (p < 0.05). Conclusions: AAU was a risk factor for AS. To identify AAU as an extra-articular manifestation is crucial for early diagnosis and treatment of AS and containing functional loss accordingly. View Full-Text
Keywords: acute anterior uveitis (AAU); ankylosing spondylitis (AS); National Health Insurance Research Database (NHIRD) acute anterior uveitis (AAU); ankylosing spondylitis (AS); National Health Insurance Research Database (NHIRD)
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yen, J.-C.; Hsu, C.-A.; Hsiao, S.-H.; Hsu, M.-H. Acute Anterior Uveitis as a Risk Factor of Ankylosing Spondylitis—A National Population-Based Study. Int. J. Environ. Res. Public Health 2017, 14, 107.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top