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Int. J. Environ. Res. Public Health 2016, 13(7), 697; doi:10.3390/ijerph13070697

2,4,6-Tribromophenol Interferes with the Thyroid Hormone System by Regulating Thyroid Hormones and the Responsible Genes in Mice

1
Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Korea
2
Laboratory of Veterinary Biochemistry, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea
3
Laboratory of Biochemistry, Department of Biomaterial Science, College of Natural Resources and Life Science, Pusan National University, Miryang, Kyeongnam 50463, Korea
4
Laboratory of Veterinary Biotechnology and Embryology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Korea
5
Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Huixiao Hong
Received: 15 February 2016 / Revised: 17 June 2016 / Accepted: 7 July 2016 / Published: 12 July 2016
(This article belongs to the Special Issue Endocrine Disruptors and Public Health)
View Full-Text   |   Download PDF [1392 KB, uploaded 12 July 2016]   |  

Abstract

2,4,6-Tribromophenol (TBP) is a brominated flame retardant (BFR). Based on its affinity for transthyretin, TBP could compete with endogenous thyroid hormone. In this study, the effects of TBP on the thyroid hormone system were assessed in mice. Briefly, animals were exposed to 40 and 250 mg/kg TBP. Thyroid hormones were also administered with or without TBP. When mice were treated with TBP, deiodinase 1 (Dio1) and thyroid hormone receptor β isoform 2 (Thrβ2) decreased in the pituitary gland. The levels of deiodinase 2 (Dio2) and growth hormone (Gh) mRNA increased in response to 250 mg/kg of TBP, and the relative mRNA level of thyroid stimulating hormone β (Tshβ) increased in the pituitary gland. Dio1 and Thrβ1 expression in the liver were not altered, while Dio1 decreased in response to co-treatment with thyroid hormones. The thyroid gland activity decreased in response to TBP, as did the levels of free triiodothyronine and free thyroxine in serum. Taken together, these findings indicate that TBP can disrupt thyroid hormone homeostasis and the presence of TBP influenced thyroid actions as regulators of gene expression. These data suggest that TBP interferes with thyroid hormone systems View Full-Text
Keywords: endocrine disruptor; 2,4,6-tribromophenol; thyroid hormone endocrine disruptor; 2,4,6-tribromophenol; thyroid hormone
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, D.; Ahn, C.; Hong, E.-J.; An, B.-S.; Hyun, S.-H.; Choi, K.-C.; Jeung, E.-B. 2,4,6-Tribromophenol Interferes with the Thyroid Hormone System by Regulating Thyroid Hormones and the Responsible Genes in Mice. Int. J. Environ. Res. Public Health 2016, 13, 697.

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