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Int. J. Environ. Res. Public Health 2016, 13(6), 615; doi:10.3390/ijerph13060615

Children and Adolescents with Perinatal HIV-1 Infection: Factors Associated with Adherence to Treatment in the Brazilian Context

Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral 178, Rio de JaneiroRJ 20221-161, Brazil
Department of Maternal and Child Care, School of Medicine, Fluminense Federal University, Rua Marquês de Paraná, 303, Niterói RJ 24033-900, Brazil
Health Information, Fundação Oswaldo Cruz, Biblioteca de Manguinhos suite 229, Av. Brasil 4365, Rio de Janeiro RJ 21045-900, Brazil
Department of Pediatrics, Instituto de Medicina Integral Prof. Fernando Figueira, Rua dos Coelhos 300, Recife PE 50070-550, Brazil
Department of Pediatrics, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Av. Pedro Teixeira 25, D Pedro I, Manaus AM 69040-000, Brazil
Centro de Doenças Infecciosas e Parasitárias de Campo Grande, Rua Bahia 280, Jardim dos Estados, Campo Grande MS 79002-380, Brazil
Department of Pediatrics, Hospital Fêmina, Grupo Hospitalar Conceição, Rua Mostardeiro 17, Moinhos de Vento, Porto Alegre RS 90430-001, Brazil
Laboratory of Environmental and Health Education, Instituto Oswaldo Cruz, Fiocruz. Av. Brasil 4365, Rio de Janeiro RJ 21045-900, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Karin Nielsen-Saines
Received: 26 April 2016 / Revised: 10 June 2016 / Accepted: 15 June 2016 / Published: 21 June 2016
(This article belongs to the Special Issue Pediatric Infectious Diseases)
View Full-Text   |   Download PDF [450 KB, uploaded 21 June 2016]   |  


Challenges to the adherence to combination antiretroviral therapy among the pediatric population should be understood in the context of the trajectories of families, their interaction with healthcare services, and their access to material and symbolic goods. The present study analyzed individual, institutional and social factors that might be associated with the caregivers’ role in the treatment adherence of children and adolescents living with HIV (CALHIV). Based on semi-structured interviews and questionnaires applied to 69 caregivers seen at pediatric AIDS services of five Brazilian macro-regions, we observed that adherent caregivers had better acceptance of diagnosis and treatment, were less likely to face discrimination and social isolation secondary to AIDS-related stigma and tended to believe in the efficacy of treatment, and to be more optimistic about life perspectives of CALHIV. Interventions aiming to improve adherence and to promote the health of CALHIV should take in consideration the interplay of such different factors. View Full-Text
Keywords: patient adherence; HIV infection; children; adolescents; vulnerability; caregivers patient adherence; HIV infection; children; adolescents; vulnerability; caregivers

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cruz, M.L.S.; Cardoso, C.A.A.; Darmont, M.Q.; Dickstein, P.; Bastos, F.I.; Souza, E.; Andrade, S.D.; Fabbro, M.D.; Fonseca, R.; Monteiro, S. Children and Adolescents with Perinatal HIV-1 Infection: Factors Associated with Adherence to Treatment in the Brazilian Context. Int. J. Environ. Res. Public Health 2016, 13, 615.

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