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Int. J. Environ. Res. Public Health 2016, 13(4), 421; doi:10.3390/ijerph13040421

A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans

1
Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, Edegem 2650, Belgium
2
Toxicology Centre, University of Antwerp, Wilrijk 2610, Belgium
3
Department of Clinical Pharmacology, Antwerp University Hospital, University of Antwerp, Edegem 2650, Belgium
*
Author to whom correspondence should be addressed.
Academic Editor: Huixiao Hong
Received: 26 January 2016 / Revised: 6 April 2016 / Accepted: 11 April 2016 / Published: 13 April 2016
(This article belongs to the Special Issue Endocrine Disruptors and Public Health)
View Full-Text   |   Download PDF [309 KB, uploaded 13 April 2016]

Abstract

Background: Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (HO-PCBs) interfere with thyroid hormone action both in vitro and in vivo. However, epidemiologic studies on the link between PCB exposure and thyroid function have yielded discordant results, while very few data are available for HO-PCBs. Objectives: Our study aimed at investigating the relationship between clinically available markers of thyroid metabolism and serum levels of both PCBs and HO-PCBs. Subjects and Methods: In a group of 180 subjects, thyroid-stimulating hormone (TSH) and free thyroxin (fT4), 29 PCBs (expressed both in lipid weight and in wet weight) and 18 HO-PCBs were measured in serum. Results: In regression models, adjusted for gender, age, current smoking behavior, BMI and total lipid levels, serum levels of 3HO-PCB118 and 3HO-PCB180, and PCB95lw, PCB99lw and PCB149lw were independent, significant predictors of fT4. A stepwise, multiple regression with gender, age, current smoking behavior, BMI and total lipid levels and all five previously identified significant compounds retained age, BMI, PCB95lw, PCB99lw and 3HO-PCB180 as significant predictors of fT4. TSH levels were not predicted by serum levels of any of the PCBs or HO-PCBs. Conclusions: Our study indicates that in vivo, circulating fT4 levels can be linked to serum levels of several PCBs and hydroxylated PCB metabolites. View Full-Text
Keywords: polychlorinated biphenyls; hydroxylated polychlorinated biphenyls; thyroid function; human; endocrine disrupters polychlorinated biphenyls; hydroxylated polychlorinated biphenyls; thyroid function; human; endocrine disrupters
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dirinck, E.; Dirtu, A.C.; Malarvannan, G.; Covaci, A.; Jorens, P.G.; Van Gaal, L.F. A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans. Int. J. Environ. Res. Public Health 2016, 13, 421.

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