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Int. J. Environ. Res. Public Health 2016, 13(4), 379; doi:10.3390/ijerph13040379

The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants

1
NIH/NIMHD RCMI Center for Environmental Heath, College of Science, Engineering, and Technology (CSET), Jackson State University, Jackson, MS 39217, USA
2
Department of Biology, CSET, Jackson State University, Jackson, MS 39217, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 31 December 2015 / Revised: 11 March 2016 / Accepted: 14 March 2016 / Published: 29 March 2016
View Full-Text   |   Download PDF [309 KB, uploaded 29 March 2016]

Abstract

Exposure to environmental hazards has been associated with diseases in humans. The identification of single nucleotide polymorphisms (SNPs) in human populations exposed to different environmental hazards, is vital for detecting the genetic risks of some important human diseases. Several studies in this field have been conducted on glutathione S-transferases (GSTs), a phase II detoxification superfamily, to investigate its role in the occurrence of diseases. Human GSTs consist of cytosolic and microsomal superfamilies that are further divided into subfamilies. Based on scientific search engines and a review of the literature, we have found a large amount of published articles on human GST super- and subfamilies that have greatly assisted in our efforts to examine their role in health and disease. Because of its polymorphic variations in relation to environmental hazards such as air pollutants, cigarette smoke, pesticides, heavy metals, carcinogens, pharmaceutical drugs, and xenobiotics, GST is considered as a significant biomarker. This review examines the studies on gene-environment interactions related to various diseases with respect to single nucleotide polymorphisms (SNPs) found in the GST superfamily. Overall, it can be concluded that interactions between GST genes and environmental factors play an important role in human diseases. View Full-Text
Keywords: gene-environment interactions; glutathione S-transferases (GSTs); single nucleotide polymorphisms (SNPs); carcinogens; xenobiotics; heavy-metals; air pollutants gene-environment interactions; glutathione S-transferases (GSTs); single nucleotide polymorphisms (SNPs); carcinogens; xenobiotics; heavy-metals; air pollutants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hollman, A.L.; Tchounwou, P.B.; Huang, H.-C. The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants. Int. J. Environ. Res. Public Health 2016, 13, 379.

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