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Int. J. Environ. Res. Public Health 2016, 13(12), 1258; doi:10.3390/ijerph13121258

Effect of 5-HT2A Receptor Polymorphisms, Work Stressors, and Social Support on Job Strain among Petroleum Workers in Xinjiang, China

Department of Occupational and Environmental Health, College of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: William A. Toscano
Received: 31 August 2016 / Revised: 3 December 2016 / Accepted: 14 December 2016 / Published: 19 December 2016
(This article belongs to the Section Global Health)
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Previous studies have shown that work stressors and social support influence job strain. However, few studies have examined the impact of individual differences on job strain. In Xinjiang, there are a large number of petroleum workers in arid deserts. The present study investigated the effects of work stressors, social support, and 5-hydroxytryptamine receptor (5-HTR2A) genotype on the etiology of job strain among petroleum workers in Xinjiang. A cross-sectional study was carried out between January and August 2013. A total of 700 workers were selected by a three-stage stratified sampling method. 5-HTR2A genotypes were determined with the SNaPshot single nucleotide polymorphism assay. Work stressors and job strain were evaluated with the Occupational Stress Inventory-Revised questionnaire. Social support was assessed with the Chinese Social Support Rating Scale. Work overload and responsibility were significantly associated with job strain. Low social support was associated with severe vocational and interpersonal strain. High social support was a protective factor against job strain (odds ratio (OR) = 0.32, 95% confidence interval (CI): 0.14–0.76). The CC genotype of rs6313 and the AA genotype of rs2070040 were linked to severe vocational strain. Ordinal logistic regression analysis revealed that the CC genotype of rs6313 was linked to higher risk of job strain than the TT genotype (OR = 1.88, 95% CI: 1.10–3.23). These data provide evidence that work stressors, low social support, and 5-HTR2A gene polymorphism contributes to the risk of job strain. View Full-Text
Keywords: job strain; work stressors; social support; 5-HTR2A; polymorphism job strain; work stressors; social support; 5-HTR2A; polymorphism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jiang, Y.; Tang, J.; Li, R.; Zhao, J.; Song, Z.; Ge, H.; Lian, Y.; Liu, J. Effect of 5-HT2A Receptor Polymorphisms, Work Stressors, and Social Support on Job Strain among Petroleum Workers in Xinjiang, China. Int. J. Environ. Res. Public Health 2016, 13, 1258.

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