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Int. J. Environ. Res. Public Health 2016, 13(12), 1254; doi:10.3390/ijerph13121254

On-Line Monitoring the Growth of E. coli or HeLa Cells Using an Annular Microelectrode Piezoelectric Biosensor

1
School of Biological and Chemical Engineering, Nanyang Institute of Technology, Nanyang 473000, China
2
School of Chemistry and Materials Engineering, Huaihua University, Huaihua 418000, China
3
School of Mechanical and Automotive Engineering, Nanyang Institute of Technology, Nanyang 473000, China
*
Author to whom correspondence should be addressed.
Academic Editor: Huang-Tsung Chang
Received: 17 September 2016 / Revised: 27 November 2016 / Accepted: 30 November 2016 / Published: 18 December 2016
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Abstract

Biological information is obtained from the interaction between the series detection electrode and the organism or the physical field of biological cultures in the non-mass responsive piezoelectric biosensor. Therefore, electric parameter of the electrode will affect the biosensor signal. The electric field distribution of the microelectrode used in this study was simulated using the COMSOL Multiphysics analytical tool. This process showed that the electric field spatial distribution is affected by the width of the electrode finger or the space between the electrodes. In addition, the characteristic response of the piezoelectric sensor constructed serially with an annular microelectrode was tested and applied for the continuous detection of Escherichia coli culture or HeLa cell culture. Results indicated that the piezoelectric biosensor with an annular microelectrode meets the requirements for the real-time detection of E. coli or HeLa cells in culture. Moreover, this kind of piezoelectric biosensor is more sensitive than the sensor with an interdigital microelectrode. Thus, the piezoelectric biosensor acts as an effective analysis tool for acquiring online cell or microbial culture information. View Full-Text
Keywords: annular microelectrodes; piezoelectric frequency; biosensor annular microelectrodes; piezoelectric frequency; biosensor
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Tong, F.; Lian, Y.; Han, J. On-Line Monitoring the Growth of E. coli or HeLa Cells Using an Annular Microelectrode Piezoelectric Biosensor. Int. J. Environ. Res. Public Health 2016, 13, 1254.

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