Overview of Cotinine Cutoff Values for Smoking Status Classification
AbstractWhile cotinine is commonly used as a biomarker to validate self-reported smoking status, the selection of an optimal cotinine cutoff value for distinguishing true smokers from true nonsmokers shows a lack of standardization among studies. This review describes how the cutoff values have been derived, and explains the issues involved in the generalization of a cutoff value. In this study, we conducted an English-language literature search in PubMed using the keywords “cotinine” and “cutoff” or “self-reported” and “smoking status” and “validation” for the years 1985–2014. We obtained 104 articles, 32 of which provided (1) sensitivity and specificity of a cutoff value and (2) determination methods for the given cutoff value. We found that the saliva cotinine cutoff value range of 10–25 ng/mL, serum and urine cotinine cutoff of 10–20 ng/mL and 50–200 ng/mL, respectively, have been commonly used to validate self-reported smoking status using a 2 × 2 table or a receiver operating characteristics (ROC) curve. We also found that recent large population-based studies in the U.S. and UK reported lower cutoff values for cotinine in serum (3 ng/mL) and saliva (12 ng/mL), compared to the traditionally accepted ones (15 and 14 ng/mg, respectively). View Full-Text
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Kim, S. Overview of Cotinine Cutoff Values for Smoking Status Classification. Int. J. Environ. Res. Public Health 2016, 13, 1236.
Kim S. Overview of Cotinine Cutoff Values for Smoking Status Classification. International Journal of Environmental Research and Public Health. 2016; 13(12):1236.Chicago/Turabian Style
Kim, Sungroul. 2016. "Overview of Cotinine Cutoff Values for Smoking Status Classification." Int. J. Environ. Res. Public Health 13, no. 12: 1236.
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