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Int. J. Environ. Res. Public Health 2016, 13(12), 1233; doi:10.3390/ijerph13121233

The Association of Hypertriglyceridemic Waist Phenotype with Chronic Kidney Disease and Its Sex Difference: A Cross-Sectional Study in an Urban Chinese Elderly Population

1
Department of Epidemiology, Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, Beijing 100853, China
2
Department of Chinese Traditional Medicine and Acupuncture, Chinese PLA General Hospital, Beijing 100853, China
3
State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, Beijing 100853, China
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Clifton
Received: 23 September 2016 / Revised: 2 December 2016 / Accepted: 6 December 2016 / Published: 13 December 2016
(This article belongs to the Section Global Health)
View Full-Text   |   Download PDF [290 KB, uploaded 13 December 2016]

Abstract

Background: The primary objective of this study was to explore the association of hypertriglyceridemic waist (HTGW) phenotype with chronic kidney disease (CKD) and its sex difference in an urban Chinese elderly population. Methods: In a cross-sectional study, a total of 2102 participants aged 60–95 years were recruited and classified into four phenotypes: normal waist-normal triglyceride (NWNT), normal waist-elevated triglycerides (NWET), elevated waist-normal triglycerides (EWNT), and HTGW. Logistic regression analysis was used to estimate the associations of interest. Results: Total prevalence of CKD was 12.6%, and the CKD prevalence in participants with EWNT and HTGW was higher than with NWNT and NWET without regard to sex. Compared to NWNT phenotype, the adjusted OR for CKD was 1.95 (95% CI: 1.32–2.88) in HTGW groups. In contrast with the null findings (OR: 1.66; 95% CI: 0.94–2.94) in women after additional adjustment for diabetes and hypertension, the OR with HTGW remained strong (OR: 1.88; 95% CI: 1.04–3.39) in men. Similar findings appeared with the EWNT phenotype. Conclusions: The HTGW phenotype is positively associated with CKD among Chinese community elderly and may have a greater impact on men. More attention should be paid to the association between triglycerides and waist circumference in clinical practice and to the further identification this uncertain sex-related association. View Full-Text
Keywords: hypertriglyceridemic waist phenotype; chronic kidney disease; cross-sectional study hypertriglyceridemic waist phenotype; chronic kidney disease; cross-sectional study
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zeng, J.; Liu, M.; Wu, L.; Wang, J.; Yang, S.; Wang, Y.; Yao, Y.; Jiang, B.; He, Y. The Association of Hypertriglyceridemic Waist Phenotype with Chronic Kidney Disease and Its Sex Difference: A Cross-Sectional Study in an Urban Chinese Elderly Population. Int. J. Environ. Res. Public Health 2016, 13, 1233.

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