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Int. J. Environ. Res. Public Health 2016, 13(11), 1173; doi:10.3390/ijerph13111173

Effects of Fetal Exposure to Asian Sand Dust on Development and Reproduction in Male Offspring

1
Department of Health and Sciences, Oita University of Nursing and Health Sciences, Oita 870-1201, Japan
2
Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Fukuoka 807-8555, Japan
3
Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, Shenyang 110122, China
4
Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8540, Japan
5
Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Hyunok Choi and Birgit Claus Henn
Received: 20 September 2016 / Revised: 15 November 2016 / Accepted: 16 November 2016 / Published: 23 November 2016
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Abstract

In recent experimental studies, we reported the aggravating effects of Asian sand dust (ASD) on male reproduction in mice. However, the effects of fetal ASD exposure on male reproduction have not been investigated. The present study investigated the effects of fetal ASD exposure on reproduction in male offspring. Using pregnant CD-1 mice, ASD was administered intratracheally on days 7 and 14 of gestation, and the reproduction of male offspring was determined at 5, 10, and 15 weeks after birth. The secondary sex ratio was significantly lower in the fetal ASD-exposed mice than in the controls. Histologic examination showed partial vacuolation of seminiferous tubules in immature mice. Moreover, daily sperm production (DSP) was significantly less in the fetal ASD-exposed mice than in the controls. DSP in the fetal ASD-exposed mice was approximately 10% less than the controls at both 5 and 10 weeks. However, both the histologic changes and the DSP decrease were reversed as the mice matured. These findings suggest that ASD exposure affects both the fetal development and the reproduction of male offspring. In the future, it will be necessary to clarify the onset mechanisms of ASD-induced male fetus death and male reproductive disorders. View Full-Text
Keywords: Asian sand dust; in utero exposure; secondary sex ratio; male reproduction; daily sperm production Asian sand dust; in utero exposure; secondary sex ratio; male reproduction; daily sperm production
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MDPI and ACS Style

Yoshida, S.; Ichinose, T.; Arashidani, K.; He, M.; Takano, H.; Shibamoto, T. Effects of Fetal Exposure to Asian Sand Dust on Development and Reproduction in Male Offspring. Int. J. Environ. Res. Public Health 2016, 13, 1173.

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