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Int. J. Environ. Res. Public Health 2016, 13(11), 1149; doi:10.3390/ijerph13111149

Sub-Acute Toxicity Study of Graphene Oxide in the Sprague-Dawley Rat

1
Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China
2
Preventive Medicine, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
3
Pediatric Specialty of Clinical Medicine, Academy of Pediatrics, Chongqing Medical University, Chongqing 400016, China
4
The First Clinical College of Chongqing Medical University, Chongqing 400016, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Peter S. Spencer
Received: 1 July 2016 / Revised: 17 October 2016 / Accepted: 7 November 2016 / Published: 17 November 2016
(This article belongs to the Special Issue Environmental Neurotoxicology)
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Abstract

Graphene oxide (GO) is an oxidized derivative of graphene used in biotechnology and medicine. The safety of GO is uncertain, so we evaluated its toxicity in male rats. Rat tail veins were injected with 2.5, 5, or 10 mg/kg GO for seven days and behavioral patterns, pathology, and tissue morphology were assessed. Data show that behaviors were not altered according to an open field test and a functional observational battery test, but histopathological analysis indicated that GO caused inflammation of the lung, liver, and spleen. GO also reduced cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL). No other organs were modified. Thus, high concentrations of GO are toxic for the lung, liver, and spleen, but the mechanism by which this occurs requires more study. View Full-Text
Keywords: graphene oxide; carbon nano-material; sub-acute toxicology graphene oxide; carbon nano-material; sub-acute toxicology
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Li, Y.; Wang, Y.; Tu, L.; Chen, D.; Luo, Z.; Liu, D.; Miao, Z.; Feng, G.; Qing, L.; Wang, S. Sub-Acute Toxicity Study of Graphene Oxide in the Sprague-Dawley Rat. Int. J. Environ. Res. Public Health 2016, 13, 1149.

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