Sub-Acute Toxicity Study of Graphene Oxide in the Sprague-Dawley Rat
AbstractGraphene oxide (GO) is an oxidized derivative of graphene used in biotechnology and medicine. The safety of GO is uncertain, so we evaluated its toxicity in male rats. Rat tail veins were injected with 2.5, 5, or 10 mg/kg GO for seven days and behavioral patterns, pathology, and tissue morphology were assessed. Data show that behaviors were not altered according to an open field test and a functional observational battery test, but histopathological analysis indicated that GO caused inflammation of the lung, liver, and spleen. GO also reduced cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL). No other organs were modified. Thus, high concentrations of GO are toxic for the lung, liver, and spleen, but the mechanism by which this occurs requires more study. View Full-Text
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Li, Y.; Wang, Y.; Tu, L.; Chen, D.; Luo, Z.; Liu, D.; Miao, Z.; Feng, G.; Qing, L.; Wang, S. Sub-Acute Toxicity Study of Graphene Oxide in the Sprague-Dawley Rat. Int. J. Environ. Res. Public Health 2016, 13, 1149.
Li Y, Wang Y, Tu L, Chen D, Luo Z, Liu D, Miao Z, Feng G, Qing L, Wang S. Sub-Acute Toxicity Study of Graphene Oxide in the Sprague-Dawley Rat. International Journal of Environmental Research and Public Health. 2016; 13(11):1149.Chicago/Turabian Style
Li, Yingbo; Wang, Yan; Tu, Liu; Chen, Di; Luo, Zhi; Liu, Dengyuan; Miao, Zhuang; Feng, Gang; Qing, Li; Wang, Shali. 2016. "Sub-Acute Toxicity Study of Graphene Oxide in the Sprague-Dawley Rat." Int. J. Environ. Res. Public Health 13, no. 11: 1149.
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