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Int. J. Environ. Res. Public Health 2016, 13(11), 1139; doi:10.3390/ijerph13111139

The Association between Arrhythmia and Helicobacter pylori Infection: A Meta-Analysis of Case-Control Studies

1,2,†
,
2,3,†
,
1,2,†
,
2,4
and
1,2,*
1
Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
2
The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China
3
Department of Gastroenterology, Yangzhou NO.1 People’s Hospital, Yangzhou 225001, China
4
Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Clifton
Received: 19 July 2016 / Revised: 22 October 2016 / Accepted: 24 October 2016 / Published: 16 November 2016
View Full-Text   |   Download PDF [3973 KB, uploaded 16 November 2016]   |  

Abstract

Arrhythmia is a common disease around the world and Helicobacter pylori (H. pylori) is a bacterium infecting 28% to 84% of subjects, depending on the population tested. However, the implication of H. pylori in cardiac arrhythmia is poorly understood. We performed this meta-analysis with an aim to identify the association between arrhythmia and H. pylori. We searched PubMed, Embase, Web of Science, and the Cochrane library databases to select studies on the association between arrhythmia and H. pylori. In the arrhythmia group, 392 (58.1%) were H. pylori-positive and in the control group 640 (47.8%) were H. pylori-positive. Compared to the controls, the infection rate of H. pylori was higher in patients with arrhythmia than in controls (odds ratio (OR) = 1.797, 95% confidence interval (CI): 1.081–2.988, p < 0.05). Subgroup analysis indicated that H. pylori infection was a risk factor for atrial fibrillation in Asia and Africa. Therefore, a correlation between H. pylori infection and arrhythmia may exist and H. pylori eradication may decrease the occurrence of arrhythmia, especially in Asia and Africa. View Full-Text
Keywords: Helicobacter pylori; arrhythmia; meta-analysis Helicobacter pylori; arrhythmia; meta-analysis
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MDPI and ACS Style

Yan, J.; She, Q.; Zhang, Y.; Cui, C.; Zhang, G. The Association between Arrhythmia and Helicobacter pylori Infection: A Meta-Analysis of Case-Control Studies. Int. J. Environ. Res. Public Health 2016, 13, 1139.

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