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Int. J. Environ. Res. Public Health 2016, 13(10), 1022;

The Association between LIPC rs493258 Polymorphism and the Susceptibility to Age-Related Macular Degeneration

6,* , 1,* and 3,*
The First Affiliated Hospital of Xi’an Jiaotong University, College of Medicine, Xi’an Jiaotong University, Xi’an 710061, China
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
Department of Public Health, Xi’an Medical University, Xi’an 710021, China
School of Humanities, Xi’an Jiaotong University, Xi’an 710049, China
Department of Internal Medicine, Xi’an Honghui Hospital, Xi’an 710054, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 15 August 2016 / Revised: 25 September 2016 / Accepted: 8 October 2016 / Published: 18 October 2016
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The purpose of this study was to evaluate the association of the hepatic lipase (LIPC) rs493258 polymorphism and susceptibility to age-related macular degeneration (AMD). A systematic search in PubMed, EMBASE, and ISI web of science databases was performed to identify eligible published studies without language restrictions up to April 2016. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) in different stages of AMD were estimated under different genetic models using meta-analytic methods. Seven studies comprising 20,559 cases and 17,200 controls met the inclusion criteria and were included in the meta-analysis. The LIPC rs493258 polymorphism showed a significant association with a lower risk of AMD under the allelic model (OR = 0.87, 95% CI = 0.84–0.90). Significant relationships between the variant and AMD were also observed in other genetic models (OR ranging from 0.71 to 0.86, all p < 0.05). Stratified analysis based on ethnicity found that LIPC rs493258 polymorphism had a significant association with the decreased risk of the disease in the Caucasian population, but not in the Asian population. For late AMD, significant associations of the rs493258 polymorphism with a lower risk of this disease were also observed in the allelic genetic model (OR = 0.87, 95% CI = 0.83–0.90). This meta-analysis demonstrates that the T allele in the LIPC rs493258 polymorphism was significantly associated with the risk of any and late AMD. The associations of the locus with early and late AMD risk in various populations need further exploration. View Full-Text
Keywords: age-related macular degeneration; LIPC; polymorphism; meta-analysis age-related macular degeneration; LIPC; polymorphism; meta-analysis

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Wang, Y.; Wang, M.; Zhang, X.; Nie, J.; Zhang, M.; Liu, X.; Ma, L. The Association between LIPC rs493258 Polymorphism and the Susceptibility to Age-Related Macular Degeneration. Int. J. Environ. Res. Public Health 2016, 13, 1022.

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