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Int. J. Environ. Res. Public Health 2016, 13(10), 1016; doi:10.3390/ijerph13101016

Polymorphism of the XRCC1 Gene Is Associated with Susceptibility and Short-Term Recovery of Ischemic Stroke

1
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
2
Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
3
Department of Neurology, Medical College, The Affiliated Jiangyin People’s Hospital of Southeast University, Wuxi 214400, China
4
Department of Neurology, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 1 September 2016 / Revised: 8 October 2016 / Accepted: 13 October 2016 / Published: 17 October 2016
(This article belongs to the Section Global Health)
View Full-Text   |   Download PDF [610 KB, uploaded 17 October 2016]   |  

Abstract

Background: Base excision repair (BER) is the primary DNA repair system with the ability to fix base lesions caused by oxidative damage. Genetic variants influencing the BER pathway may affect the susceptibility and the outcomes of ischemic stroke. Here, we examined how single nucleotide polymorphisms (SNPs) associated with BER impact susceptibility and short-term recovery of ischemic stroke. Methods: We selected 320 ischemic stroke patients and 303 controls. Then we genotyped SNPs of NEIL1 rs4462560, NEIL3 rs12645561 and XRCC1 rs25487 in both groups. Results: Polymorphism in XRCC1 rs25487 was significantly associated with reduced ischemic stroke (IS) risk (dominant model: OR = 0.53, 95% CI = 0.36–0.79, p = 0.002), a milder initial stroke (dominant model: OR = 0.57, 95% CI = 0.33–0.98, p = 0.043), and also a better short-term recovery (dominant model: OR = 0.57, 95% CI = 0.35–0.92, p = 0.022). No association was observed in the other two SNPs. Conclusions: Our study suggests that the genetic variant of XRCC1 rs25487 may contribute to the etiology of ischemic stroke. View Full-Text
Keywords: ischemic stroke; SNPs; XRCC1; base excision repair; prognosis ischemic stroke; SNPs; XRCC1; base excision repair; prognosis
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MDPI and ACS Style

He, W.; Huang, P.; Liu, D.; Zhong, L.; Yu, R.; Li, J. Polymorphism of the XRCC1 Gene Is Associated with Susceptibility and Short-Term Recovery of Ischemic Stroke. Int. J. Environ. Res. Public Health 2016, 13, 1016.

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