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Int. J. Environ. Res. Public Health 2016, 13(10), 1003; doi:10.3390/ijerph13101003

The Impact of Secondhand Smoke Exposure on Children with Cystic Fibrosis: A Review

1
Section of Pediatric Pulmonology, Nationwide Children’s Hospital, Columbus, OH 43205, USA
2
Center for Microbial Pathogenesis, The Research Institute at Nationwide Children’s Hospital, Columbus, OH 43205, USA
3
Paediatric Environmental Health Specialty Unit, Department of Pediatrics, Clinical University Hospital Virgen of Arrixaca, Murcia 30120, Spain
4
Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins School of Medicine, Baltimore, MD 20205, USA
5
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
6
Section of Ambulatory Pediatrics, Nationwide Children’s Hospital, Columbus, OH 43205, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Laura L. Jones and Amanda Farley
Received: 5 August 2016 / Revised: 7 October 2016 / Accepted: 7 October 2016 / Published: 12 October 2016
(This article belongs to the Special Issue Exposure and Health Effects of Secondhand Smoke)
View Full-Text   |   Download PDF [285 KB, uploaded 12 October 2016]

Abstract

Secondhand smoke exposure (SHSe) has multiple adverse effects on lung function and growth, nutrition, and immune function in children; it is increasingly being recognized as an important modifier of disease severity for children with chronic diseases such as cystic fibrosis (CF). This review examines what is known regarding the prevalence of SHSe in CF, with the majority of reviewed studies utilizing parental-reporting of SHSe without an objective biomarker of exposure. A wide range of SHSe is reported in children with CF, but under-reporting is common in studies involving both reported and measured SHSe. Additionally, the impact of SHSe on respiratory and nutritional health is discussed, with potential decreases in long-term lung function, linear growth, and weight gain noted in CF children with SHSe. Immunologic function in children with CF and SHSe remains unknown. The impact of SHSe on cystic fibrosis transmembrane conductance regulator (CFTR) function is also examined, as reduced CFTR function may be a pathophysiologic consequence of SHSe in CF and could modulate therapeutic interventions. Finally, potential interventions for ongoing SHSe are delineated along with recommended future areas of study. View Full-Text
Keywords: tobacco; cystic fibrosis; pediatric tobacco; cystic fibrosis; pediatric
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kopp, B.T.; Ortega-García, J.A.; Sadreameli, S.C.; Wellmerling, J.; Cormet-Boyaka, E.; Thompson, R.; McGrath-Morrow, S.; Groner, J.A. The Impact of Secondhand Smoke Exposure on Children with Cystic Fibrosis: A Review. Int. J. Environ. Res. Public Health 2016, 13, 1003.

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