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Int. J. Environ. Res. Public Health 2016, 13(1), 103; doi:10.3390/ijerph13010103

Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study

1
División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco 86205, México
2
División Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco 86650, México
3
División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco Villahermosa, Tabasco 86150, México
4
Hospital General de Yajalón. Secretaría de Salud, Yajalón, Chiapas 29932, México
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 10 November 2015 / Revised: 15 December 2015 / Accepted: 28 December 2015 / Published: 6 January 2016
View Full-Text   |   Download PDF [593 KB, uploaded 6 January 2016]   |  

Abstract

Background: The C-reactive protein (CRP) and the tumor necrosis factor-alpha (TNF-α) are considered markers of inflammation and have been shown to predict the risk of incident cardiovascular events. However, few studies have undertaken a comprehensive examination of SNPs (single nucleotide polymorphisms) of the CRP and TNF-α genes; due to this, we will present a protocol study to evaluate the role of the CRP and TNF-α genes in Mexican individuals. Methods/design: we will perform a case-control study to explore the CRP and TNF-α genotype distribution as well as the serum influence of rs1800947, rs1130864, rs2794521 and rs1205 (polymorphisms of the CRP gene) and rs361525, rs1800629, rs1799724, rs1800630, rs1799964 (of the TNF-α gene) in Mexican individuals who present coronary artery disease. Ethics and dissemination: a written informed consent will be obtained from all the participating subjects. An article detailing the results of the study will be submitted for publication in an international peer-reviewed journal, in accordance with STROBE criteria. View Full-Text
Keywords: CAD; CRP; TNF-α; association studies; Mexican population CAD; CRP; TNF-α; association studies; Mexican population
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hernández-Díaz, Y.; Tovilla-Zárate, C.A.; Juárez-Rojop, I.; López-Narváez, M.L.; Álvarez-Cámara, J.F.; González-Castro, T.B. Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study. Int. J. Environ. Res. Public Health 2016, 13, 103.

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