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Int. J. Environ. Res. Public Health 2015, 12(8), 9454-9474; doi:10.3390/ijerph120809454

Dengue Vaccines: A Perspective from the Point of View of Intellectual Property

Pontifical Catholic University of Paraná, PUCPR, Rua Imaculada Conceição, 1155 Prado Velho, 80215-901 Curitiba, PR, Brazil
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Ching-To Ma
Received: 19 June 2015 / Revised: 2 August 2015 / Accepted: 5 August 2015 / Published: 12 August 2015
(This article belongs to the Special Issue Health Economics)
View Full-Text   |   Download PDF [2815 KB, uploaded 13 August 2015]   |  


Dengue is a serious infectious disease and a growing public health problem in many tropical and sub-tropical countries. To control this neglected tropical disease (NTD), vaccines are likely to be the most cost-effective solution. This study analyzed dengue vaccines from both a historical and longitudinal perspective by using patent data, evaluating the geographic and time coverage of innovations, the primary patent holders, the network of cooperation and partnership for vaccine research and development (R & D), the flow of knowledge and the technological domain involved. This study can be seen as an example of the use of patent information to inform policy discussions, strategic research planning, and technology transfer. The results show that 93% of patents were granted since 2000, the majority belonging to the United States and Europe, although the share of patents from developing countries has increased. Unlike another NTDs, there is great participation of private companies in R & D of dengue vaccines and partnerships and collaboration between public and private companies. Finally, in this study, the main holders showed high knowledge absorption and generated capabilities. Therefore, this issue suggests that to overcome the difficulty of translational R & D it is necessary to stimulate the generation of knowledge and relevant scientific research, to enable the productive sector to have the capacity to absorb knowledge, to turn it into innovation, and to articulate partnerships and collaboration. View Full-Text
Keywords: viruses; heath public; innovation; patent; pharmaceutical industry; dengue virus; neglected tropical disease viruses; heath public; innovation; patent; pharmaceutical industry; dengue virus; neglected tropical disease

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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da Veiga, C.P.; da Veiga, C.R.P.; Del Corso, J.M.; da Silva, W.V. Dengue Vaccines: A Perspective from the Point of View of Intellectual Property. Int. J. Environ. Res. Public Health 2015, 12, 9454-9474.

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