Next Article in Journal
Assessing the Variability of Heavy Metal Concentrations in Liquid-Solid Two-Phase and Related Environmental Risks in the Weihe River of Shaanxi Province, China
Previous Article in Journal
Possible Internalization of an Enterovirus in Hydroponically Grown Lettuce
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2015, 12(7), 8228-8242; doi:10.3390/ijerph120708228

Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population

1
Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China
2
Department of Nephrology, Huhhot First Hospital, Huhhot, Inner Mongolia 010010, China
3
Department of Nephrology, The First Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia 010010, China
4
Department of Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, China
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 3 May 2015 / Revised: 24 June 2015 / Accepted: 30 June 2015 / Published: 17 July 2015
View Full-Text   |   Download PDF [789 KB, uploaded 17 July 2015]

Abstract

Objective: To assess the high-sensitivity C-reactive protein (hs-CRP) levels and explore the risk factors for an elevated hs-CRP level. We also provide the clinical utility of CRP to identify subjects with metabolic syndrome (MetS). Methods: Data were drawn from a cross-sectional survey in China. Subjects were divided into three subgroups: hs-CRP ≤ 1 mg/L, 1 mg/L < hs-CRP ≤ 3 mg/L and hs-CRP > 3 mg/L. Multiple linear regressions and logistic regression models were used. Results: In the Chinese population, 50.43% subjects had a low hs-CRP level, 30.21% subjects had an intermediate hs-CRP level and 19.36% subjects had an elevated hs-CRP level. Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and urinary albumin to creatinine ratio (ACR) were correlated with log-CRP. In multivariate analysis, relative risks of an elevated CRP level were 2.40 (95% CI 1.44–3.99, p = 0.001), 3.63 (95% CI 2.20–5.98, p < 0.001), 4.23 (95% CI 2.51–7.11, p < 0.001) and 6.23 (95% CI 3.45–11.26, p < 0.001) for subjects with 1, 2, 3, or more than 3 MetS components, respectively. The accurate estimates of the area under the receiver operating characteristic of hs-CRP for MetS was 0.6954 (95% CI, 0.67–0.72). Conclusion: Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and ACR are correlated with log-CRP. The number of MetS components is a significant determinant of elevated CRP levels after adjusted for other potential confounders. View Full-Text
Keywords: C-reactive protein; metabolic disorder C-reactive protein; metabolic disorder
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sun, M.; Zhang, L.; Chen, S.; Liu, X.; Shao, X.; Zou, H. Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population. Int. J. Environ. Res. Public Health 2015, 12, 8228-8242.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top