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Int. J. Environ. Res. Public Health 2015, 12(7), 8228-8242; doi:10.3390/ijerph120708228

Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population

Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China
Department of Nephrology, Huhhot First Hospital, Huhhot, Inner Mongolia 010010, China
Department of Nephrology, The First Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia 010010, China
Department of Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, China
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 3 May 2015 / Revised: 24 June 2015 / Accepted: 30 June 2015 / Published: 17 July 2015
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Objective: To assess the high-sensitivity C-reactive protein (hs-CRP) levels and explore the risk factors for an elevated hs-CRP level. We also provide the clinical utility of CRP to identify subjects with metabolic syndrome (MetS). Methods: Data were drawn from a cross-sectional survey in China. Subjects were divided into three subgroups: hs-CRP ≤ 1 mg/L, 1 mg/L < hs-CRP ≤ 3 mg/L and hs-CRP > 3 mg/L. Multiple linear regressions and logistic regression models were used. Results: In the Chinese population, 50.43% subjects had a low hs-CRP level, 30.21% subjects had an intermediate hs-CRP level and 19.36% subjects had an elevated hs-CRP level. Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and urinary albumin to creatinine ratio (ACR) were correlated with log-CRP. In multivariate analysis, relative risks of an elevated CRP level were 2.40 (95% CI 1.44–3.99, p = 0.001), 3.63 (95% CI 2.20–5.98, p < 0.001), 4.23 (95% CI 2.51–7.11, p < 0.001) and 6.23 (95% CI 3.45–11.26, p < 0.001) for subjects with 1, 2, 3, or more than 3 MetS components, respectively. The accurate estimates of the area under the receiver operating characteristic of hs-CRP for MetS was 0.6954 (95% CI, 0.67–0.72). Conclusion: Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and ACR are correlated with log-CRP. The number of MetS components is a significant determinant of elevated CRP levels after adjusted for other potential confounders. View Full-Text
Keywords: C-reactive protein; metabolic disorder C-reactive protein; metabolic disorder
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sun, M.; Zhang, L.; Chen, S.; Liu, X.; Shao, X.; Zou, H. Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population. Int. J. Environ. Res. Public Health 2015, 12, 8228-8242.

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