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Int. J. Environ. Res. Public Health 2015, 12(5), 4942-4966; doi:10.3390/ijerph120504942

Ninety Day Toxicity and Toxicokinetics of Fluorochloridone after Oral Administration in Rats

1
School of Public Health, Fudan University, Shanghai 200032, China
2
Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
*
Author to whom correspondence should be addressed.
Academic Editor: Howard W. Mielke
Received: 10 March 2015 / Revised: 16 April 2015 / Accepted: 24 April 2015 / Published: 6 May 2015
(This article belongs to the Special Issue Lead: Risk Assessment and Health Effects)
View Full-Text   |   Download PDF [4738 KB, uploaded 6 May 2015]   |  

Abstract

The ninety day toxicity and toxicokinetics of fluorochloridone (FLC) were accessed in Wistar rats. Animals were gavaged with FLC at doses of 31.25 mg/kg, 125 mg/kg and 500 mg/kg for ninety days, followed by thirty days for recovery. On the 1st, 60th, 75th and 90th days of the dosing phase, plasma of ten animals of all groups treated with FLC was collected for toxicokinetic analysis of FLC by an UPLC-MS/MS method. Numerous changes in body weight, hematology, serum chemistry, and organ weight ratios were observed by the 45th and 90th dosing day. Most changes in groups treated with FLC were absent on the last recovery day. Testis and epididymis lesions were consistently seen in histopathological observations on the 45th, 90th dosing day and the last recovery day. Repeated administration of FLC increased the level of testosterone in serum in male rats on the 90th dosing day. FLC plasma concentrations could be detected in all animal drug-treated groups during the dosing phase, and a dose proportional relationship was seen between FLC dose and AUC or Cmax. This study will support future studies on the mechanism of FLC-induced toxicity. View Full-Text
Keywords: fluorochloridone; ninety days toxicity; gavage; toxicokinetics; UPLC-MS/MS; rat fluorochloridone; ninety days toxicity; gavage; toxicokinetics; UPLC-MS/MS; rat
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhang, S.; Cheng, X.; Wang, Y.; Fan, J.; Li, R.; Zhou, S.; Liu, S.; Shi, J.; Sun, J.; Hu, Y.; Xu, C.; Wu, C.; Chang, X.; Tang, L.; Zhou, Z. Ninety Day Toxicity and Toxicokinetics of Fluorochloridone after Oral Administration in Rats. Int. J. Environ. Res. Public Health 2015, 12, 4942-4966.

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