Next Article in Journal
Overweight and Obese Adolescent Girls: The Importance of Promoting Sensible Eating and Activity Behaviors from the Start of the Adolescent Period
Previous Article in Journal
Air Pollution and Daily Clinic Visits for Headache in a Subtropical City: Taipei, Taiwan
Article Menu

Export Article

Open AccessReview
Int. J. Environ. Res. Public Health 2015, 12(2), 2289-2305; doi:10.3390/ijerph120202289

Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases

1
Department of Endocrinology and Nephrology, Centre Hospitalier Universitaire de Québec Research Centre, Québec, QC, G1V 4G2, Canada
2
Division of Rheumatology, Department of Medicine, University Laval, Québec, QC, G1V 4G2, Canada
3
Department of Rheumatology, Centre Hospitalier Universitaire de Québec, Québec, QC, G1V 4G2, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 22 November 2014 / Revised: 13 January 2015 / Accepted: 11 February 2015 / Published: 17 February 2015
View Full-Text   |   Download PDF [716 KB, uploaded 17 February 2015]

Abstract

Atmospheric pollution-induced cellular oxidative stress is probably one of the pathogenic mechanisms involved in most of the common autophagy-mediated aging diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, disease, as well as Paget’s disease of bone with or without frontotemporal dementia and inclusion body myopathy. Oxidative stress has serious damaging effects on the cellular contents: DNA, RNA, cellular proteins, and cellular organelles. Autophagy has a pivotal role in recycling these damaged non-functional organelles and misfolded or unfolded proteins. In this paper, we highlight, through a narrative review of the literature, that when autophagy processes are impaired during aging, in presence of cumulative air pollution-induced cellular oxidative stress and due to a direct effect on air pollutant, autophagy-mediated aging diseases may occur. View Full-Text
Keywords: Paget’s disease of bone; neurodegenerative diseases; autophagy; SQSTM1/p62; oxidative stress; cigarettes; tobacco smoke; wood heating; air pollutants; aging Paget’s disease of bone; neurodegenerative diseases; autophagy; SQSTM1/p62; oxidative stress; cigarettes; tobacco smoke; wood heating; air pollutants; aging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Numan, M.S.; Brown, J.P.; Michou, L. Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases. Int. J. Environ. Res. Public Health 2015, 12, 2289-2305.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top