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Int. J. Environ. Res. Public Health 2015, 12(10), 13542-13559; doi:10.3390/ijerph121013542

Altered Hippocampal Lipid Profile Following Acute Postnatal Exposure to Di(2-Ethylhexyl) Phthalate in Rats

1
Department of Neuroscience, Carleton University, 1125 Colonel By Drive, 325 LSRB, Ottawa ON, K1S 5B6, Canada
2
Department of Chemistry, Carleton University, Ottawa, 1125 Colonel By Drive, SC-226, Ottawa, ON, K1S5B6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 3 September 2015 / Revised: 14 October 2015 / Accepted: 20 October 2015 / Published: 27 October 2015
(This article belongs to the Special Issue Environmental Neurotoxicology)
View Full-Text   |   Download PDF [1314 KB, uploaded 27 October 2015]   |  

Abstract

Slight changes in the abundance of certain lipid species in the brain may drastically alter normal neurodevelopment via membrane stability, cell signalling, and cell survival. Previous findings have demonstrated that postnatal exposure to di (2-ethylhexyl) phthalate (DEHP) disrupts normal axonal and neural development in the hippocampus. The goal of the current study was to determine whether postnatal exposure to DEHP alters the lipid profile in the hippocampus during postnatal development. Systemic treatment with 10 mg/kg DEHP during postnatal development led to elevated levels of phosphatidylcholine and sphingomyelin in the hippocampus of female rats. There was no effect of DEHP exposure on the overall abundance of phosphatidylcholine or sphingomyelin in male rats or of lysophosphatidylcholine in male or female rats. Individual analyses of each identified lipid species revealed 10 phosphatidylcholine and six sphingomyelin lipids in DEHP-treated females and a single lysophosphatidylcholine in DEHP-treated males with a two-fold or higher increase in relative abundance. Our results are congruent with previous work that found that postnatal exposure to DEHP had a near-selective detrimental effect on hippocampal development in males but not females. Together, results suggest a neuroprotective effect of these elevated lipid species in females. View Full-Text
Keywords: Hippocampus; phthalate; mass spectrometry; sphingolipids; phosphatidylcholine; Lysophosphatidylcholine Hippocampus; phthalate; mass spectrometry; sphingolipids; phosphatidylcholine; Lysophosphatidylcholine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Smith, C.A.; Farmer, K.; Lee, H.; Holahan, M.R.; Smith, J.C. Altered Hippocampal Lipid Profile Following Acute Postnatal Exposure to Di(2-Ethylhexyl) Phthalate in Rats. Int. J. Environ. Res. Public Health 2015, 12, 13542-13559.

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