The Effects of Leptin on Breastfeeding Behaviour
AbstractBreastfed infants have a reduced risk of becoming overweight and/or obese later in life. This protective effect has been partly attributed to leptin present in breastmilk. This study investigated 24-h variations of skim milk leptin and its relationship with breastmilk macronutrients and infant breastfeeding patterns. Exclusive breastfeeding mothers of term singletons (n = 19; age 10 ± 5 weeks) collected pre- and post-feed breastmilk samples for every breastfeed over a 24-h period and test-weighed their infants to determine milk intake at every breastfeed over a 24-h period. Samples (n = 454) were analysed for leptin, protein, lactose and fat content. Skim milk leptin concentration did not change with feeding (p = 0.184). However, larger feed volumes (>105 g) were associated with a decrease in post-feed leptin levels (p = 0.009). There was no relationship between the change in leptin levels and change in protein (p = 0.313) or lactose levels (p = 0.587) between pre- and post-feed milk, but there was a trend for a positive association with changes in milk fat content (p = 0.056). Leptin concentration significantly increased at night (p < 0.001) indicating a possible 24-h pattern. Leptin dose (ng) was not associated with the time between feeds (p = 0.232). Further research should include analysis of whole breastmilk and other breastmilk fractions to extend these findings. View Full-Text
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Cannon, A.M.; Kakulas, F.; Hepworth, A.R.; Lai, C.T.; Hartmann, P.E.; Geddes, D.T. The Effects of Leptin on Breastfeeding Behaviour. Int. J. Environ. Res. Public Health 2015, 12, 12340-12355.
Cannon AM, Kakulas F, Hepworth AR, Lai CT, Hartmann PE, Geddes DT. The Effects of Leptin on Breastfeeding Behaviour. International Journal of Environmental Research and Public Health. 2015; 12(10):12340-12355.Chicago/Turabian Style
Cannon, Anna M.; Kakulas, Foteini; Hepworth, Anna R.; Lai, Ching T.; Hartmann, Peter E.; Geddes, Donna T. 2015. "The Effects of Leptin on Breastfeeding Behaviour." Int. J. Environ. Res. Public Health 12, no. 10: 12340-12355.