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Int. J. Environ. Res. Public Health 2015, 12(1), 268-281; doi:10.3390/ijerph120100268

Evaluation of the Relationship between 5-HTT and MAO Gene Polymorphisms, Mood and Level of Anxiety among Postmenopausal Women

1
Department of Nursing, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, Poland
2
Department of Clinical Psychology, Institute of Psychology, University of Szczecin, 69 Krakowska St., 71-017 Szczecin, Poland
3
Department of Informatics and Health Statistics, Institute of Rural Health, 2 Jaczewskiego St., 20-090 Lublin, Poland
4
Department of Public Health, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, Poland
5
Department of Psychiatry, Pomeranian Medical University in Szczecin, 26 Broniewskiego St., 71-460 Szczecin, Poland
6
Department of Gynaecology and Urogynaecology, Pomeranian Medical University in Szczecin, 2 Siedlecka St., 71-010 Police, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 29 September 2014 / Accepted: 15 December 2014 / Published: 24 December 2014
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Abstract

Objective: The aim of this study was to analyze how mood and anxiety level are related to the functional genetic polymorphism in the promoter region of SLC6A4 (5-HTTLPR) and the 30-bp VNTR polymorphism in the MAO A promoter region. Methods: The study involved 272 postmenopausal women from Poland. The authors employed the State-Trait Anxiety Inventory for measuring levels of anxiety, the Mood Adjective Check List for measuring mood, and genetic tests. Results: Analysis did not show any statistically significant differences in the mean levels of anxiety, and mood disorders in women in relation to genotypes of the 5-HTTLPR (SLC6A4) polymorphism and the 30-bp VNTR polymorphism in the MAO A promoter region. However, these problems were more severe among women with s/s genotype. In the case of MAO A gene polymorphism, the level of anxiety was higher in women with a 4/4 genotype. Conclusions: The study did not prove the possibility of the identification of homogeneous groups of women with an elevated risk of developing anxiety and mood disorders during the post-menopausal period. Nevertheless, it showed that respondents with s/s genotype of the 44-bp polymorphism in the 5-HTT (SLC6A4) promoter region had the highest average anxiety levels both as a state and as a trait. Furthermore, the analysis of the 30-bp VNTR polymorphism in the MAO A promoter region demonstrated slight differences in anxiety levels between the women, indicating that those with a 4/4 genotype had higher severity of anxiety symptoms. View Full-Text
Keywords: mood disorders; postmenopause; 5HTTLPR; MAO A; anxiety mood disorders; postmenopause; 5HTTLPR; MAO A; anxiety
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Grochans, E.; Jurczak, A.; Szkup, M.; Samochowiec, A.; Włoszczak-Szubzda, A.; Karakiewicz, B.; Grzywacz, A.; Brodowska, A.; Samochowiec, J. Evaluation of the Relationship between 5-HTT and MAO Gene Polymorphisms, Mood and Level of Anxiety among Postmenopausal Women. Int. J. Environ. Res. Public Health 2015, 12, 268-281.

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