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Int. J. Environ. Res. Public Health 2014, 11(5), 4926-4938; doi:10.3390/ijerph110504926
Case Report

Perchlorate Exposure and Thyroid Function in Ammonium Perchlorate Workers in Yicheng, China

1,2,†
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Received: 24 January 2014; in revised form: 28 April 2014 / Accepted: 29 April 2014 / Published: 7 May 2014
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Abstract: The impact of low level dust on the thyroid function of workers chronically exposed to ammonium perchlorate (AP) is uncertain and controversial. The aim of this study was to examine whether workers in China with long-term (>3 years) occupational exposure to low levels of AP dust had affected thyroid homeostasis. Mean occupational exposures to AP dust ranged from 0.43 to 1.17 mg/m3. Geometric means of post-shift urinary perchlorate levels were 20.5 µg/L for those exposed and 12.8 µg/L for the controls. No significant differences were found for thyroid function parameters of FT3, FT4, or log TSH or for TPO prevalence or thyroglobulin levels. Additionally, no differences in findings were observed for complete blood count (CBC), serum biochemical profile, or pulmonary function test. Median urinary iodine levels of 172 and 184 µg/L showed that the workers had sufficient iodine intake. This study found no effect on thyroid function from long term, low-level documented exposure to ammonium perchlorate. It is the first study to report both thyroid status parameters and urinary perchlorate, a biomarker of internal perchlorate exposure, in occupationally exposed workers in China.
Keywords: ammonium perchlorate; thyroid; occupational exposure; biomarker ammonium perchlorate; thyroid; occupational exposure; biomarker
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, H.; Wu, L.; Wang, X.; Liu, Q.; Ding, M.; Peng, K.; Meng, Z. Perchlorate Exposure and Thyroid Function in Ammonium Perchlorate Workers in Yicheng, China. Int. J. Environ. Res. Public Health 2014, 11, 4926-4938.

AMA Style

Chen H, Wu L, Wang X, Liu Q, Ding M, Peng K, Meng Z. Perchlorate Exposure and Thyroid Function in Ammonium Perchlorate Workers in Yicheng, China. International Journal of Environmental Research and Public Health. 2014; 11(5):4926-4938.

Chicago/Turabian Style

Chen, Hongxia; Wu, Libing; Wang, Xia; Liu, Qin; Ding, Miaohong; Peng, Kailiang; Meng, Zhongji. 2014. "Perchlorate Exposure and Thyroid Function in Ammonium Perchlorate Workers in Yicheng, China." Int. J. Environ. Res. Public Health 11, no. 5: 4926-4938.


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