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Int. J. Environ. Res. Public Health 2014, 11(5), 4870-4885; doi:10.3390/ijerph110504870

Hematological and Biochemical Data Obtained in Rural Northern Uganda

1 Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan 2 Med Biotech Laboratories, P.O. Box 9364, Kampala, Uganda 3 Proteo-Science Center, Ehime University, 3 Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan 4 Makerere University School of Public Health, P.O. Box 7072, Kampala, Uganda 5 The Research Foundation for Microbial Diseases of Osaka University, 2-9-41 Yahata-cho, Kanonji, Kagawa 768-0061, Japan 6 The London School of Economics and Political Science, Houghton Street, London WC2A 2AE, UK 7 Lira Medical Center, Lira, Uganda 8 Muhimbili University of Health and Allied Sciences, United Nations Road, Dar es Salaam, P.O. Box 65001, Tanzania
* Author to whom correspondence should be addressed.
Received: 26 February 2014 / Revised: 21 April 2014 / Accepted: 30 April 2014 / Published: 6 May 2014
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Reference intervals for common hematological and clinical chemistry parameters constitute an important basis for health care. Moreover, with increasing priority in drug and vaccine development for infectious diseases in Africa, the first priority is the safety evaluation and tolerability of the candidate interventions in healthy populations. To accurately assess health status and address adverse events, clinical reference intervals in the target population are necessary. We report on hematological and biochemical indices from healthy volunteers who participated in a clinical trial in Lira, northern Uganda. Median and nonparametric 95% percentiles on five hematology and 15 biochemistry analytes are shown. Although most hematological analytes conformed to reported reference intervals and trends in Africa, literature review from different African countries highlight the need for a region-specific children reference interval that can be appropriate for the population.
Keywords: reference intervals; clinical trials; hematology; biochemistry; adult reference values; children reference values reference intervals; clinical trials; hematology; biochemistry; adult reference values; children reference values
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Palacpac, N.M.Q.; Ntege, E.; Balikagala, B.; Yeka, A.; Shirai, H.; Suzuki, N.; Nsereko, C.; Kanoi, B.N.; Okada, T.; Egwang, T.G.; Horii, T. Hematological and Biochemical Data Obtained in Rural Northern Uganda. Int. J. Environ. Res. Public Health 2014, 11, 4870-4885.

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