Next Article in Journal
Previous Article in Journal
Int. J. Environ. Res. Public Health 2014, 11(4), 3639-3649; doi:10.3390/ijerph110403639
Article

Association of Influenza Vaccination and Reduced Risk of Stroke Hospitalization among the Elderly: A Population-Based Case-Control Study

1,2
, 3
, 1
 and 1,4,*
Received: 24 January 2014; in revised form: 13 March 2014 / Accepted: 19 March 2014 / Published: 2 April 2014
View Full-Text   |   Download PDF [216 KB, uploaded 19 June 2014]
Abstract: The aim of this study was to investigate the effect of influenza vaccination (and annual revaccination) on the risk of stroke admissions. We conducted a population-based case-control study in Taiwan. Cases consisted of patients >65 years of age who had a first-time diagnosis of stroke during the influenza seasons from 2006 to 2009. Controls were selected by matching age, sex, and index date to cases. Multiple logistic regression analysis was used to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Ever vaccinated individuals in the current vaccination season were associated with a reduced risk of ischemic stroke admissions (OR = 0.76, 95% CI = 0.60–0.97). Compared with individuals never vaccinated against influenza during the past 5 years, the adjusted ORs were 0.92 (95% CI = 0.68–1.23) for the group with 1 or 2 vaccinations, 0.73 (95% CI = 0.54–1.00) for the group with 3 or 4 vaccinations, and 0.56 (95% CI = 0.38–0.83) for the group with 5 vaccinations. There was a significant trend of decreasing risk of ischemic stroke admissions with an increasing number of vaccinations. This study provides evidence that vaccination against influenza may reduce the risk of hospitalization for ischemic stroke and that annual revaccination provides greater protection.
Keywords: stroke; influenza; vaccination; hospitalization; revaccination; case-control stroke; influenza; vaccination; hospitalization; revaccination; case-control
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Lin, H.-C.; Chiu, H.-F.; Ho, S.-C.; Yang, C.-Y. Association of Influenza Vaccination and Reduced Risk of Stroke Hospitalization among the Elderly: A Population-Based Case-Control Study. Int. J. Environ. Res. Public Health 2014, 11, 3639-3649.

AMA Style

Lin H-C, Chiu H-F, Ho S-C, Yang C-Y. Association of Influenza Vaccination and Reduced Risk of Stroke Hospitalization among the Elderly: A Population-Based Case-Control Study. International Journal of Environmental Research and Public Health. 2014; 11(4):3639-3649.

Chicago/Turabian Style

Lin, Hui-Chen; Chiu, Hui-Fen; Ho, Shu-Chen; Yang, Chun-Yuh. 2014. "Association of Influenza Vaccination and Reduced Risk of Stroke Hospitalization among the Elderly: A Population-Based Case-Control Study." Int. J. Environ. Res. Public Health 11, no. 4: 3639-3649.



Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert