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Int. J. Environ. Res. Public Health 2014, 11(12), 13117-13129; doi:10.3390/ijerph111213117

Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers

Department of Epidemiology and Environmental Health, State University of New York at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA
Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin El-Kom 32511, Egypt
Clinical Pathology and Hematology and Immunology, Menoufia University, Shebin El-Kom 32511, Egypt
Department of Pharmacology and Toxicology, State University of New York at Buffalo, 102 Farber Hall, Buffalo, NY 14214, USA
Department of Occupational and Environmental Health, University of Iowa, 145 N. Riverside Drive 100 CPHB Iowa City, IA 52242, USA
Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L606 Portland, OR 97239, USA
Author to whom correspondence should be addressed.
Received: 29 October 2014 / Revised: 4 December 2014 / Accepted: 11 December 2014 / Published: 16 December 2014
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Chlorpyrifos (CPF) is a commonly used organophosphate insecticide (OP). In adults, exposure to OPs has been inconsistently associated with reduced lung function. OP exposure and lung function has not been assessed in adolescents. The objective of this study was to assess CPF exposure and lung function among Egyptian adolescents. We conducted a 10-month study of male adolescent pesticide applicators (n = 38) and non-applicators of similar age (n = 24). Urinary 3,5,6-trichloro-2-pyridinol (TPCy), a CPF-specific metabolite, was analyzed in specimens collected throughout the study. Spirometry was performed twice after pesticide application: day 146, when TCPy levels were elevated and day 269, when TCPy levels were near baseline. Applicators had higher levels of TCPy (mean cumulative TCPy day 146 = 33,217.6; standard deviation (SD) = 49,179.3) than non-applicators (mean cumulative TCPy day 146 = 3290.8; SD = 3994.9). Compared with non-applicators, applicators had higher odds of reporting wheeze, odds ratio = 3.41 (95% CI: 0.70; 17.41). Cumulative urinary TCPy was inversely associated with spirometric measurements at day 146, but not at day 269. Although generally non-significant, results were consistent with an inverse association between exposure to CPF and lung function. View Full-Text
Keywords: chlorpyrifos; lung function; adolescents chlorpyrifos; lung function; adolescents

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Callahan, C.L.; Al-Batanony, M.; Ismail, A.A.; Abdel-Rasoul, G.; Hendy, O.; Olson, J.R.; Rohlman, D.S.; Bonner, M.R. Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers. Int. J. Environ. Res. Public Health 2014, 11, 13117-13129.

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