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Int. J. Environ. Res. Public Health 2014, 11(12), 12108-12117;

Vitamin D and Psoriasis Pathology in the Mediterranean Region, Valencia (Spain)

Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
Center for Advanced Research in Public Health (CSISP-FISABIO), 46010 Valencia, Spain
Sunlight, Nutrition and Health Research Center, P.O. Box 641603, San Francisco, CA 94164, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 15 September 2014 / Revised: 4 November 2014 / Accepted: 18 November 2014 / Published: 25 November 2014
(This article belongs to the Special Issue Preventive Medicine)
Full-Text   |   PDF [674 KB, uploaded 26 November 2014]   |  


Vitamin D has important immunomodulatory effects on psoriasis in the Mediterranean region. To measure vitamin D intake in subjects with and without psoriasis, and to find an association with relevant clinical features, a case-control study was performed using cases (n = 50, 50% participation rate) clinically diagnosed with psoriasis and 200 healthy subjects (39.5% participation rate), leaving a final sample of 104 people. A survey was conducted using a food frequency questionnaire and clinical histories. Cases and controls were compared using univariate and multivariate analyses. We observed insufficient intake of cholecalciferol (vitamin D3) or ergocalciferol (vitamin D2) for both cases and controls. Patients with psoriasis were at greater risk of associated pathologies: dyslipidaemia (OR: 3.6, 95% CI: 0.8–15.2); metabolic syndrome (OR: 3.3, 95% CI: 0.2–53.9); hypertension (OR: 1.7, 95% CI: 0.4–7.2). Insufficient vitamin D intake in both psoriasis patients and controls in the Mediterranean population, and cardiovascular comorbility is more frequent in patients with psoriasis. View Full-Text
Keywords: vitamin D; psoriasis; Mediterranean region; diet vitamin D; psoriasis; Mediterranean region; diet

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Suárez-Varela, M.M.; Reguera-Leal, P.; Grant, W.B.; Rubio-López, N.; Llopis-González, A. Vitamin D and Psoriasis Pathology in the Mediterranean Region, Valencia (Spain). Int. J. Environ. Res. Public Health 2014, 11, 12108-12117.

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