Next Article in Journal
Functional Validity of a Judgment Skills Measure within the Concept of Health Literacy for Sleeping Disorder Patients
Next Article in Special Issue
Multivariate Optimization for Extraction of Pyrethroids in Milk and Validation for GC-ECD and CG-MS/MS Analysis
Previous Article in Journal
Sociobehavioral Factors Associated with Caries Increment: A Longitudinal Study from 24 to 36 Months Old Children in Thailand
Previous Article in Special Issue
Evaluation of Toxic Metals and Essential Elements in Children with Learning Disabilities from a Rural Area of Southern Brazil
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2014, 11(10), 10851-10867; doi:10.3390/ijerph111010851

Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline?

1
Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
2
Post-graduate Program in Pharmaceutical Sciences (PPGCF), Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
3
Department of Chemistry, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, RJ 22451-900, Brazil
4
Institute of Psychology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS 90035-003, Brazil
5
Post-graduate Program of Biochemistry, Federal University of Pampa, Uruguaiana, RS 97500-970, Brazil
*
Author to whom correspondence should be addressed.
Received: 16 June 2014 / Revised: 16 September 2014 / Accepted: 25 September 2014 / Published: 17 October 2014
View Full-Text   |   Download PDF [726 KB, uploaded 17 October 2014]

Abstract

Aging is often accompanied by cognitive impairments and influenced by oxidative status and chemical imbalances. Thus, this study was conducted to examine whether age-related cognitive deficit is associated with oxidative damage, especially with inhibition of the enzyme delta-aminolevulinate dehydratase (ALA-D), as well as to verify the influence of some metals in the enzyme activity and cognitive performance. Blood ALA-D activity, essential (Fe, Zn, Cu, Se) and non-essential metals (Pb, Cd, Hg, As, Cr, Ni, V) were measured in 50 elderly and 20 healthy young subjects. Cognitive function was assessed by tests from Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) battery and other. The elderly group presented decreased ALA-D activity compared to the young group. The index of ALA-D reactivation was similar to both study groups, but negatively associated with metals. The mean levels of essential metals were within the reference values, while the most toxic metals were above them in both groups. Cognitive function impairments were observed in elderly group and were associated with decreased ALA-D activity, with lower levels of Se and higher levels of toxic metals (Hg and V). Results suggest that the reduced ALA-D activity in elderly can be an additional factor involved in cognitive decline, since its inhibition throughout life could lead to accumulation of the neurotoxic compound ALA. Toxic metals were found to contribute to cognitive decline and also to influence ALA-D reactivation. View Full-Text
Keywords: ALA-D; cognitive decline; cognitive assessment; toxic metals; essential metals ALA-D; cognitive decline; cognitive assessment; toxic metals; essential metals
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Baierle, M.; Charão, M.F.; Göethel, G.; Barth, A.; Fracasso, R.; Bubols, G.; Sauer, E.; Campanharo, S.C.; Rocha, R.C.C.; Saint'Pierre, T.D.; Bordignon, S.; Zibetti, M.; Trentini, C.M.; Ávila, D.S.; Gioda, A.; Garcia, S.C. Are Delta-Aminolevulinate Dehydratase Inhibition and Metal Concentrations Additional Factors for the Age-Related Cognitive Decline? Int. J. Environ. Res. Public Health 2014, 11, 10851-10867.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top