Next Article in Journal
Enteric Pathogen Survival Varies Substantially in Irrigation Water from Belgian Lettuce Producers
Next Article in Special Issue
Evaluation of Toxic Metals and Essential Elements in Children with Learning Disabilities from a Rural Area of Southern Brazil
Previous Article in Journal
The Value of Mainstreaming Human Rights into Health Impact Assessment
Previous Article in Special Issue
In vitro and in vivo Effects of Free and Chalcones-Loaded Nanoemulsions: Insights and Challenges in Targeted Cancer Chemotherapies
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2014, 11(10), 10091-10104; doi:10.3390/ijerph111010091

Ilex paraguariensis Extract Increases Lifespan and Protects Against the Toxic Effects Caused by Paraquat in Caenorhabditis elegans

1
Programa de Pós Graduação em Bioquímica, Universidade Federal do Pampa, BR 472-Km 592-Caixa Postal 118-CEP: 97500-970-Uruguaiana-RS, Brazil
2
Faculdade de Farmácia, Universidade Federal do Pampa, BR 472-Km 592-Caixa Postal 118-CEP: 97500-970-Uruguaiana-RS, Brazil
*
Author to whom correspondence should be addressed.
Received: 21 July 2014 / Revised: 16 September 2014 / Accepted: 22 September 2014 / Published: 26 September 2014
View Full-Text   |   Download PDF [694 KB, uploaded 26 September 2014]   |  

Abstract

Recent studies have shown that phenolic compounds present in yerba mate have antioxidant defense properties. To verify whether Ilex paraguariensis extracts are capable of increasing the lifespan of an organism, we have used the free-living nematode Caenorhabditis elegans. Notably, this is the first study that analyzes the effects of the extracts of yerba mate obtained from an extraction method that mimics the manner that the plant is consumed by the population by using a live organism. Yerba mate was purchased from commercial markets from Argentina, Brazil, and Uruguay. Ilex paraguariensis extracts significantly increased the life span of C. elegans. Moreover, the extracts reduced the ROS levels per se, and protected from the reduced survival and reproduction rate induced by paraquat exposure. Considering molecular aspects, we observed that the worms pretreated with the extracts depicted higher translocation of the transcription factor DAF-16::GFP to the nucleus. However, there was no increase in the levels of the DAF-16 target genes, SOD-3 and catalase. Our results suggest that the increase of lifespan caused by the different extracts is associated to the antioxidant potential of yerba mate, however this effect is not completely mediated by daf-16. View Full-Text
Keywords: paraquat; oxidative stress; Ilex paraguariensis paraquat; oxidative stress; Ilex paraguariensis
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lima, M.E.; Colpo, A.C.; Salgueiro, W.G.; Sardinha, G.E.; Ávila, D.S.; Folmer, V. Ilex paraguariensis Extract Increases Lifespan and Protects Against the Toxic Effects Caused by Paraquat in Caenorhabditis elegans. Int. J. Environ. Res. Public Health 2014, 11, 10091-10104.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top