Next Article in Journal
Aberrant Production of Th1/Th2/Th17-Related Cytokines in Serum of C57BL/6 Mice after Short-Term Formaldehyde Exposure
Next Article in Special Issue
Ilex paraguariensis Extract Increases Lifespan and Protects Against the Toxic Effects Caused by Paraquat in Caenorhabditis elegans
Previous Article in Journal / Special Issue
Genomic Instability in Human Lymphocytes from Male Users of Crack Cocaine
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2014, 11(10), 10016-10035; doi:10.3390/ijerph111010016

In vitro and in vivo Effects of Free and Chalcones-Loaded Nanoemulsions: Insights and Challenges in Targeted Cancer Chemotherapies

1
Department of Pharmaceutical Sciences, Federal University of Santa Catarina, P.O. Box 476, Florianópolis, SC 88040-900, Brazil
2
Department of Pharmacy, University of West of Santa Catarina, Videira, SC 89560-000, Brazil
3
Department of Chemistry, Federal University of Santa Catarina, P.O. Box 476, Florianópolis, SC 88040-900, Brazil
*
Author to whom correspondence should be addressed.
Received: 15 July 2014 / Revised: 29 August 2014 / Accepted: 4 September 2014 / Published: 26 September 2014
View Full-Text   |   Download PDF [1247 KB, uploaded 29 September 2014]   |  

Abstract

Several obstacles are encountered in conventional chemotherapy, such as drug toxicity and poor stability. Nanotechnology is envisioned as a strategy to overcome these effects and to improve anticancer therapy. Nanoemulsions comprise submicron emulsions composed of biocompatible lipids, and present a large surface area revealing interesting physical properties. Chalcones are flavonoid precursors, and have been studied as cytotoxic drugs for leukemia cells that induce cell death by different apoptosis pathways. In this study, we encapsulated chalcones in a nanoemulsion and compared their effect with the respective free compounds in leukemia and in non-tumoral cell lines, as well as in an in vivo model. Free and loaded-nanoemulsion chalcones induced a similar anti-leukemic effect. Free chalcones induced higher toxicity in VERO cells than chalcones-loaded nanoemulsions. Similar results were observed in vivo. Free chalcones induced a reduction in weight gain and liver injuries, evidenced by oxidative stress, as well as an inflammatory response. Considering the high toxicity and the side effects induced generally by all cancer chemotherapies, nanotechnology provides some options for improving patients’ life quality and/or increasing survival rates. View Full-Text
Keywords: nanomedicine; nanoemulsion; chalcones; leukemia; chemotherapy nanomedicine; nanoemulsion; chalcones; leukemia; chemotherapy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Winter, E.; Pizzol, C.D.; Locatelli, C.; Silva, A.H.; Conte, A.; Chiaradia-Delatorre, L.D.; Nunes, R.J.; Yunes, R.A.; Creckzynski-Pasa, T.B. In vitro and in vivo Effects of Free and Chalcones-Loaded Nanoemulsions: Insights and Challenges in Targeted Cancer Chemotherapies. Int. J. Environ. Res. Public Health 2014, 11, 10016-10035.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top