Next Article in Journal
Previous Article in Journal
Int. J. Environ. Res. Public Health 2013, 10(8), 3233-3245; doi:10.3390/ijerph10083233
Article

Hypothyroxinemia Induced by Mild Iodine Deficiency Deregulats Thyroid Proteins during Gestation and Lactation in Dams

1,2
, 1,2
, 1,2
, 1
, 1
, 1
, 2
, 2
, 1,3
 and 1,2,*
Received: 21 June 2013; in revised form: 24 July 2013 / Accepted: 26 July 2013 / Published: 2 August 2013
View Full-Text   |   Download PDF [299 KB, uploaded 19 June 2014]
Abstract: The main object of the present study was to explore the effect on thyroidal proteins following mild iodine deficiency (ID)-induced maternal hypothyroxinemia during pregnancy and lactation. In the present study, we established a maternal hypothyroxinemia model in female Wistar rats by using a mild ID diet. Maternal thyroid iodine content and thyroid weight were measured. Expressions of thyroid-associated proteins were analyzed. The results showed that the mild ID diet increased thyroid weight, decreased thyroid iodine content and increased expressions of thyroid transcription factor 1, paired box gene 8 and Na+/Iāˆ’ symporter on gestational day (GD) 19 and postpartum days (PN) 21 in the maternal thyroid. Moreover, the up-regulated expressions of type 1 iodothyronine deiodinase (DIO1) and type 2 iodothyronine deiodinase (DIO2) were detected in the mild ID group on GD19 and PN21. Taken together, our data indicates that during pregnancy and lactation, a maternal mild ID could induce hypothyroxinemia and increase the thyroidal DIO1 and DIO2 levels.
Keywords: mild iodine deficiency; hypothyroxinemia; gestation; lactation; thyroid mild iodine deficiency; hypothyroxinemia; gestation; lactation; thyroid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Wei, W.; Wang, Y.; Dong, J.; Wang, Y.; Min, H.; Song, B.; Shan, Z.; Teng, W.; Xi, Q.; Chen, J. Hypothyroxinemia Induced by Mild Iodine Deficiency Deregulats Thyroid Proteins during Gestation and Lactation in Dams. Int. J. Environ. Res. Public Health 2013, 10, 3233-3245.

AMA Style

Wei W, Wang Y, Dong J, Wang Y, Min H, Song B, Shan Z, Teng W, Xi Q, Chen J. Hypothyroxinemia Induced by Mild Iodine Deficiency Deregulats Thyroid Proteins during Gestation and Lactation in Dams. International Journal of Environmental Research and Public Health. 2013; 10(8):3233-3245.

Chicago/Turabian Style

Wei, Wei; Wang, Yi; Dong, Jing; Wang, Yuan; Min, Hui; Song, Binbin; Shan, Zhongyan; Teng, Weiping; Xi, Qi; Chen, Jie. 2013. "Hypothyroxinemia Induced by Mild Iodine Deficiency Deregulats Thyroid Proteins during Gestation and Lactation in Dams." Int. J. Environ. Res. Public Health 10, no. 8: 3233-3245.



Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert