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Int. J. Environ. Res. Public Health 2013, 10(3), 1062-1084; doi:10.3390/ijerph10031062
Article

UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides

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Received: 1 February 2013; in revised form: 6 March 2013 / Accepted: 6 March 2013 / Published: 14 March 2013
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Abstract: Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which nitro-PAHs induce genotoxicity. Although the metabolic activation of nitro-PAHs leading to toxicological activities has been well studied, the photo-induced activation of nitro-PAHs has seldom been reported. In this paper, we report photo-induced lipid peroxidation by 19 nitro-PAHs. The results indicated that all but two of the nitro-PAHs can induce lipid peroxidation. Mechanistic studies suggest that lipid peroxidation by nitro-PAHs is mediated by free radicals generated in the reaction. There was no structural correlation between the nitro-PAHs and their ability to induce lipid peroxidation upon UVA irradiation, or between the HOMO-LUMO gap and the ability to cause lipid peroxidation. Most of the nitro-PAHs are less potent in terms of causing lipid peroxidation than their parent PAHs. The lack of correlation is attributed to the complex photophysics and photochemistry of the nitro-PAHs and the yield of reactive oxygen species (ROS) and other factors.
Keywords: nitro-polycyclic aromatic hydrocarbons; photoiradiation; UVA light; reactive oxygen species; lipid peroxidation nitro-polycyclic aromatic hydrocarbons; photoiradiation; UVA light; reactive oxygen species; lipid peroxidation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xia, Q.; Yin, J.-J.; Zhao, Y.; Wu, Y.-S.; Wang, Y.-Q.; Ma, L.; Chen, S.; Sun, X.; Fu, P.P.; Yu, H. UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides . Int. J. Environ. Res. Public Health 2013, 10, 1062-1084.

AMA Style

Xia Q, Yin J-J, Zhao Y, Wu Y-S, Wang Y-Q, Ma L, Chen S, Sun X, Fu PP, Yu H. UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides . International Journal of Environmental Research and Public Health. 2013; 10(3):1062-1084.

Chicago/Turabian Style

Xia, Qingsu; Yin, Jun-Jie; Zhao, Yuewei; Wu, Yuh-Sen; Wang, Yu-Qui; Ma, Liang; Chen, Shoujun; Sun, Xin; Fu, Peter P.; Yu, Hongtao. 2013. "UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides ." Int. J. Environ. Res. Public Health 10, no. 3: 1062-1084.



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