Next Article in Journal
Microbiological Analysis in Three Diverse Natural Geothermal Bathing Pools in Iceland
Previous Article in Journal
Observational Studies and a Statistical Early Warning of Surface Ozone Pollution in Tangshan, the Largest Heavy Industry City of North China
Int. J. Environ. Res. Public Health 2013, 10(3), 1062-1084; doi:10.3390/ijerph10031062
Article

UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides

1
, 2
, 1
, 3
, 1
, 1
, 1
, 4
, 1,†,*  and 5,*
Received: 1 February 2013 / Revised: 6 March 2013 / Accepted: 6 March 2013 / Published: 14 March 2013
View Full-Text   |   Download PDF [714 KB, 19 June 2014; original version 19 June 2014]   |   Browse Figures

Abstract

Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which nitro-PAHs induce genotoxicity. Although the metabolic activation of nitro-PAHs leading to toxicological activities has been well studied, the photo-induced activation of nitro-PAHs has seldom been reported. In this paper, we report photo-induced lipid peroxidation by 19 nitro-PAHs. The results indicated that all but two of the nitro-PAHs can induce lipid peroxidation. Mechanistic studies suggest that lipid peroxidation by nitro-PAHs is mediated by free radicals generated in the reaction. There was no structural correlation between the nitro-PAHs and their ability to induce lipid peroxidation upon UVA irradiation, or between the HOMO-LUMO gap and the ability to cause lipid peroxidation. Most of the nitro-PAHs are less potent in terms of causing lipid peroxidation than their parent PAHs. The lack of correlation is attributed to the complex photophysics and photochemistry of the nitro-PAHs and the yield of reactive oxygen species (ROS) and other factors.
Keywords: nitro-polycyclic aromatic hydrocarbons; photoiradiation; UVA light; reactive oxygen species; lipid peroxidation nitro-polycyclic aromatic hydrocarbons; photoiradiation; UVA light; reactive oxygen species; lipid peroxidation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Xia, Q.; Yin, J.-J.; Zhao, Y.; Wu, Y.-S.; Wang, Y.-Q.; Ma, L.; Chen, S.; Sun, X.; Fu, P.P.; Yu, H. UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides . Int. J. Environ. Res. Public Health 2013, 10, 1062-1084.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert