Int. J. Environ. Res. Public Health 2013, 10(11), 5459-5469; doi:10.3390/ijerph10115459
Article

Antimicrobial Effect of 7-O-Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains

1 Department of Animal Science, Iowa State University, Ames 50011, USA 2 Division of Animal Life Science, Konkuk University, Seoul 143-701, Korea 3 Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Korea 4 Department of Chemistry, Konkuk University, Seoul 143-701, Korea 5 Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea 6 Department of Animal Science and Technology, Sunchon National University, Sunchon 540-742, Korea
* Author to whom correspondence should be addressed.
Received: 5 August 2013; in revised form: 16 October 2013 / Accepted: 21 October 2013 / Published: 28 October 2013
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Abstract: The antimicrobial effect of a novel flavonoid (7-O-butylnaringenin) on Helicobacter pylori 26695, 51, and SS1 strains and its inhibitory effect on the urease activity of the strains were evaluated and compared with those of several natural flavonoids. First, various flavonoids were screened for antimicrobial activities using the paper disc diffusion method. Hesperetin and naringenin showed the strongest antimicrobial effects among the natural flavonoids tested, and thus hesperetin and naringenin were selected for comparison with 7-O-butylnaringenin. The antimicrobial effect of 7-O-butylnaringenin was greater than that of the hesperetin and naringenin. H. pylori 51 was more sensitive to 7-O-butylnaringenin (2 log reduction of colony forming units, p < 0.05) than the other two strains at 200 μM. 7-O-Butylnaringenin also showed the highest inhibitory effect against urease activity of H. pylori. Morphological changes of H. pylori 26695 treated with these flavonoids indicated that both hesperetin and 7-O-butylnaringenin at 200 μM damaged the cell membranes.
Keywords: flavonoid; Helicobacter pylori; 7-O-butylnaringenin; hesperitin; antimicrobial effect; urease activity

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MDPI and ACS Style

Moon, S.H.; Lee, J.H.; Kim, K.-T.; Park, Y.-S.; Nah, S.-Y.; Ahn, D.U.; Paik, H.-D. Antimicrobial Effect of 7-O-Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains. Int. J. Environ. Res. Public Health 2013, 10, 5459-5469.

AMA Style

Moon SH, Lee JH, Kim K-T, Park Y-S, Nah S-Y, Ahn DU, Paik H-D. Antimicrobial Effect of 7-O-Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains. International Journal of Environmental Research and Public Health. 2013; 10(11):5459-5469.

Chicago/Turabian Style

Moon, Sun H.; Lee, Jae H.; Kim, Kee-Tae; Park, Yong-Sun; Nah, Seung-Yeol; Ahn, Dong U.; Paik, Hyun-Dong. 2013. "Antimicrobial Effect of 7-O-Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains." Int. J. Environ. Res. Public Health 10, no. 11: 5459-5469.

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