Mar. Drugs 2011, 9(9), 1664-1681; doi:10.3390/md9091664
Review

Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering

Received: 22 July 2011; in revised form: 2 September 2011 / Accepted: 5 September 2011 / Published: 23 September 2011
(This article belongs to the Special Issue Marine Polysaccharides)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The therapeutic potential of natural bioactive compounds such as polysaccharides, especially glycosaminoglycans, is now well documented, and this activity combined with natural biodiversity will allow the development of a new generation of therapeutics. Advances in our understanding of the biosynthesis, structure and function of complex glycans from mammalian origin have shown the crucial role of this class of molecules to modulate disease processes and the importance of a deeper knowledge of structure-activity relationships. Marine environment offers a tremendous biodiversity and original polysaccharides have been discovered presenting a great chemical diversity that is largely species specific. The study of the biological properties of the polysaccharides from marine eukaryotes and marine prokaryotes revealed that the polysaccharides from the marine environment could provide a valid alternative to traditional polysaccharides such as glycosaminoglycans. Marine polysaccharides present a real potential for natural product drug discovery and for the delivery of new marine derived products for therapeutic applications.
Keywords: marine bacteria; marine algae; exopolysaccharides; sulfated polysaccharides; structure; chemical modification; biological activity; blue biotechnology; cell therapy; tissue engineering
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MDPI and ACS Style

Senni, K.; Pereira, J.; Gueniche, F.; Delbarre-Ladrat, C.; Sinquin, C.; Ratiskol, J.; Godeau, G.; Fischer, A.-M.; Helley, D.; Colliec-Jouault, S. Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering. Mar. Drugs 2011, 9, 1664-1681.

AMA Style

Senni K, Pereira J, Gueniche F, Delbarre-Ladrat C, Sinquin C, Ratiskol J, Godeau G, Fischer A-M, Helley D, Colliec-Jouault S. Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering. Marine Drugs. 2011; 9(9):1664-1681.

Chicago/Turabian Style

Senni, Karim; Pereira, Jessica; Gueniche, Farida; Delbarre-Ladrat, Christine; Sinquin, Corinne; Ratiskol, Jacqueline; Godeau, Gaston; Fischer, Anne-Marie; Helley, Dominique; Colliec-Jouault, Sylvia. 2011. "Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering." Mar. Drugs 9, no. 9: 1664-1681.

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