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Mar. Drugs 2011, 9(9), 1649-1663; doi:10.3390/md9091649
Article

Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan

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Received: 2 August 2011; in revised form: 6 September 2011 / Accepted: 9 September 2011 / Published: 23 September 2011
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Abstract: The controlled release of diclofenac sodium (DFNa) from a chitosan-oxidized konjac glucomannan (CTS-OKG) polymer film was studied. Konjac glucomannan (KGM) was initially oxidized by sodium periodate and then cross-linked to CTS via imine bonds (–C=N–) to form the new CTS-OKG copolymer. The DFNa loaded CTS-OKG polymers were characterized by Fourier transformed infrared spectroscopy (FT-IR) and X-ray diffractometry (XRD). Finally, the release profiles of DFNa from the CTS-OKG polymer matrices were evaluated in a simulated gastrointestinal fluid system comprised of two hours in simulated gastric fluid (SGF; pH 1.2) followed by 24 h in simulated intestinal fluid (SIF; pH 7.4). A 1:2:1 (w/w/w) ratio of CTS:OKG:DFNa prepared at room temperature for 3 hours gave the highest % encapsulation efficiency (EE) of 95.6 ± 0.6 and resulted in a minimal release of DFNa ( < 1% over 2 h) in SGF (pH 1.2) and a significantly improved sustained release in SIF (pH 7.4) with ~6% and 19% release over 8 and 24 h, respectively), some 15- and five-fold lower than that of the two commercial DFNa preparations, Diclosian and Voltaren. This formulation may be used for further study as a long term intestine controlled release drug model (at least 3 days).
Keywords: drug delivery system; diclofenac sodium; chitosan; oxidized konjac glucomannan drug delivery system; diclofenac sodium; chitosan; oxidized konjac glucomannan
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Korkiatithaweechai, S.; Umsarika, P.; Praphairaksit, N.; Muangsin, N. Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan. Mar. Drugs 2011, 9, 1649-1663.

AMA Style

Korkiatithaweechai S, Umsarika P, Praphairaksit N, Muangsin N. Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan. Marine Drugs. 2011; 9(9):1649-1663.

Chicago/Turabian Style

Korkiatithaweechai, Suphat; Umsarika, Pornpusadee; Praphairaksit, Narong; Muangsin, Nongnuj. 2011. "Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan." Mar. Drugs 9, no. 9: 1649-1663.



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