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Mar. Drugs 2011, 9(9), 1543-1553; doi:10.3390/md9091543
Article

Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides

1
,
1,2,3
,
1
,
1
,
1
,
4
,
1,5,*  and 2,3,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 3 Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan 5 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Authors to whom correspondence should be addressed.
Received: 11 August 2011 / Revised: 6 September 2011 / Accepted: 6 September 2011 / Published: 16 September 2011
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Abstract

Five new nardosinane-type sesquiterpenoids, paralemnolins Q–U (15), along with three known compounds (68), were isolated from the Formosan soft coral Paralemnalia thyrsoides. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods, and the absolute configuration of 1 was determined by the application of Mosher’s method on 1. Among these metabolites, 1 and 3 are rarely found nardosinane-type sesquiterpenoids, possessing novel polycyclic structures. Compounds 1, 3, 6 and 7 were found to possess neuroprotective activity.
Keywords: soft coral; Paralemnalia thyrsoides; nardosinane; neuroprotective activity soft coral; Paralemnalia thyrsoides; nardosinane; neuroprotective activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Huang, C.-Y.; Su, J.-H.; Chen, B.-W.; Wen, Z.-H.; Hsu, C.-H.; Dai, C.-F.; Sheu, J.-H.; Sung, P.-J. Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides. Mar. Drugs 2011, 9, 1543-1553.

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