Next Article in Journal
Characterization of a Novel Serine Protease Inhibitor Gene from a Marine Metagenome
Previous Article in Journal
Capilloquinol: A Novel Farnesyl Quinol from the Dongsha Atoll Soft Coral Sinularia capillosa
Mar. Drugs 2011, 9(9), 1477-1486; doi:10.3390/md9091477
Article

Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis

1,2
,
3
,
2
,
4
 and
1,*
1 School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan 2 Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan 3 National Research Institute of Chinese Medicine, Taipei 112, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
* Author to whom correspondence should be addressed.
Received: 8 July 2011 / Revised: 23 August 2011 / Accepted: 25 August 2011 / Published: 2 September 2011
View Full-Text   |   Download PDF [1085 KB, uploaded 24 February 2015]   |  

Abstract

Four new 8-hydroxybriarane diterpenoids, frajunolides L–O (14), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 14 were elucidated based on spectroscopic analysis, especially 2D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.
Keywords: Junceella fragilis; 8-hydroxybriarane; frajunolides; anti-inflammatory activities Junceella fragilis; 8-hydroxybriarane; frajunolides; anti-inflammatory activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Liaw, C.-C.; Kuo, Y.-H.; Lin, Y.-S.; Hwang, T.-L.; Shen, Y.-C. Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis. Mar. Drugs 2011, 9, 1477-1486.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert