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Mar. Drugs 2011, 9(9), 1477-1486; doi:10.3390/md9091477
Article

Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis

1,2
, 3
, 2
, 4
 and 1,*
1 School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan 2 Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan 3 National Research Institute of Chinese Medicine, Taipei 112, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
* Author to whom correspondence should be addressed.
Received: 8 July 2011 / Revised: 23 August 2011 / Accepted: 25 August 2011 / Published: 2 September 2011
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Abstract

Four new 8-hydroxybriarane diterpenoids, frajunolides L–O (14), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 14 were elucidated based on spectroscopic analysis, especially 2D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.
Keywords: Junceella fragilis; 8-hydroxybriarane; frajunolides; anti-inflammatory activities Junceella fragilis; 8-hydroxybriarane; frajunolides; anti-inflammatory activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liaw, C.-C.; Kuo, Y.-H.; Lin, Y.-S.; Hwang, T.-L.; Shen, Y.-C. Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis. Mar. Drugs 2011, 9, 1477-1486.

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