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Mar. Drugs 2011, 9(9), 1477-1486; doi:10.3390/md9091477

Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis

1
School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
2
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
3
National Research Institute of Chinese Medicine, Taipei 112, Taiwan
4
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
*
Author to whom correspondence should be addressed.
Received: 8 July 2011 / Revised: 23 August 2011 / Accepted: 25 August 2011 / Published: 2 September 2011
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Abstract

Four new 8-hydroxybriarane diterpenoids, frajunolides L–O (14), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 14 were elucidated based on spectroscopic analysis, especially 2D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.
Keywords: Junceella fragilis; 8-hydroxybriarane; frajunolides; anti-inflammatory activities Junceella fragilis; 8-hydroxybriarane; frajunolides; anti-inflammatory activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Liaw, C.-C.; Kuo, Y.-H.; Lin, Y.-S.; Hwang, T.-L.; Shen, Y.-C. Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis. Mar. Drugs 2011, 9, 1477-1486.

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