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Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis
School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
* Author to whom correspondence should be addressed.
Received: 8 July 2011; in revised form: 23 August 2011 / Accepted: 25 August 2011 / Published: 2 September 2011
Abstract: Four new 8-hydroxybriarane diterpenoids, frajunolides L–O (1–4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1–4 were elucidated based on spectroscopic analysis, especially 2D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.
Keywords: Junceella fragilis; 8-hydroxybriarane; frajunolides; anti-inflammatory activities
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MDPI and ACS Style
Liaw, C.-C.; Kuo, Y.-H.; Lin, Y.-S.; Hwang, T.-L.; Shen, Y.-C. Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis. Mar. Drugs 2011, 9, 1477-1486.
Liaw C-C, Kuo Y-H, Lin Y-S, Hwang T-L, Shen Y-C. Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis. Marine Drugs. 2011; 9(9):1477-1486.
Liaw, Chia-Ching; Kuo, Yao-Haur; Lin, Yun-Sheng; Hwang, Tsong-Long; Shen, Ya-Ching. 2011. "Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis." Mar. Drugs 9, no. 9: 1477-1486.